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Titolo:
RELATIONSHIP OF CYTOKINES AND CYTOKINE SIGNALING TO IMMUNODEFICIENCY DISORDERS IN THE MOUSE
Autore:
MORAWETZ RA; GIESE NA; GABRIELE L; ROTHMAN P; HORAK I; OZATO K; MORSE HC;
Indirizzi:
NIAID,IMMUNOPATHOL LAB,NIH,9000 ROCKVILLE PIKE BETHESDA MD 20892 NIAID,IMMUNOPATHOL LAB,NIH BETHESDA MD 20892 NICHHD,LAB MOL GROWTH REGULAT BETHESDA MD 20892 COLUMBIA UNIV NEW YORK NY 00000 RES INST MOL PHARMACOL,DEPT MOL GENET BERLIN GERMANY
Titolo Testata:
Brazilian journal of medical and biological research
fascicolo: 1, volume: 31, anno: 1998,
pagine: 61 - 67
SICI:
0100-879X(1998)31:1<61:ROCACS>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETROVIRUS-INDUCED IMMUNODEFICIENCY; MURINE LEUKEMIA-VIRUS; B-CELL LINEAGE; SYNDROME MAIDS; T-CELLS; AIDS VIRUS; ICSBP GENE; TH2 CELLS; MICE; RESISTANCE;
Keywords:
ICSBP; IMMUNODEFICIENCY; INTERFERON; MAIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Morawetz et al., "RELATIONSHIP OF CYTOKINES AND CYTOKINE SIGNALING TO IMMUNODEFICIENCY DISORDERS IN THE MOUSE", Brazilian journal of medical and biological research, 31(1), 1998, pp. 61-67

Abstract

The contributions of cytokines to the development and progression of disease in a mouse model of retrovirus-induced immunodeficiency (MAIDS) are controversial. Some studies have indicated an etiologic role fortype 2 cytokines, while others have emphasized the importance of type1 cytokines. We have used mice deficient in expression of IL-4, IL-10, IL-4 and IL-10, IFN-gamma, or ICSBP - a transcriptional protein involved in IFN signaling - to examine their contributions to this disorder. Our results demonstrate that expression of type 2 cytokines is an epiphenomenon of infection and that IFN-gamma is a driving force in disease progression. In addition, exogenously administered IL-12 preventsmany manifestations of disease while blocking retrovirus expression. Interruption of the IFN signaling pathways in ICSBP-/- mice blocks induction of MAIDS. Predictably, ICSBP-deficient mice exhibit impaired responses to challenge with several other viruses, This immunodeficiencyis associated with impaired production of IFN-gamma and IL-12, Unexpectedly, however, the ICSBP-/- mice also develop a syndrome with many similarities to chronic myelogenous leukemia in humans. The chronic phase of this disease is followed by a fatal blast crisis characterized by clonal expansions of undifferentiated cells, ICSBP is thus an important determinant of hematopoietic growth and differentiation as well asa prominent signaling molecule for IFNs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:50:23