Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CHANGES IN HEPATOCELLULAR INTEGRITY DURING AND AFTER DESFLURANE OR ISOFLURANE ANESTHESIA IN PATIENTS UNDERGOING BREAST SURGERY
Autore:
TIAINEN P; LINDGREN L; ROSENBERG PH;
Indirizzi:
S KARELIA CENT HOSP,DEPT ANAESTHESIA,VALTO KAKELAN KATU 1 FIN-53130 LAPPEENRANTA FINLAND UNIV HELSINKI,CENT HOSP,DEPT SURG 4,DEPT ANAESTHESIA HELSINKI FINLAND UNIV HELSINKI,DEPT BIOSCI,DIV BIOCHEM HELSINKI FINLAND UNIV HELSINKI,DEPT ANAESTHESIOL HELSINKI FINLAND
Titolo Testata:
British Journal of Anaesthesia
fascicolo: 1, volume: 80, anno: 1998,
pagine: 87 - 89
SICI:
0007-0912(1998)80:1<87:CIHIDA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTATHIONE TRANSFERASE-ALPHA; ANESTHESIA; SEVOFLURANE; HALOTHANE; SERUM;
Keywords:
ANESTHETICS VOLATILE, DESFLURANE; ANESTHETICS VOLATILE, ISOFLURANE; ENZYMES, GLUTATHIONE S-TRANSFERASE; LIVER, FUNCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
P. Tiainen et al., "CHANGES IN HEPATOCELLULAR INTEGRITY DURING AND AFTER DESFLURANE OR ISOFLURANE ANESTHESIA IN PATIENTS UNDERGOING BREAST SURGERY", British Journal of Anaesthesia, 80(1), 1998, pp. 87-89

Abstract

We have assessed hepatocellular integrity in patients anaesthetized with desflurane or isoflurane using glutathione transferase Alpha (GSTA) as a sensitive indicator. Volatile anaesthetic was administered to 72 women at 0.7 MAC for 25 min and thereafter at 1.0 MAC. GSTA was measured with a time-resolved immunofluorometric assay in serum samples. Mild or moderate increases in GSTA were found in approximately 40% of patients immediately after anaesthesia. In the desflurane group (n = 30) the increase in GSTA concentration was from a baseline value of the geometric mean of 1.3 mu g litre(-1) (95% confidence interval 0.9-1.9 mu g litre(-1)) to a peak of 2.6 (1.8-3.8) mu g litre(-1). The corresponding increase in the isoflurane group (n = 31) was from 1.3 (0.9-1.9) mu g litre(-1) to 3.0 (2.2-4.2) mu g litre(-1). The change in GSTA concentration was significant in both groups but not between groups. Nopredictive factors for the increase in GSTA concentrations were found. Increased GSTA concentrations were not accompanied by increases in aminotransferases. We conclude that desflurane and isoflurane anaesthesia were associated with a mild subclinical disturbance of hepatocellular integrity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 15:18:58