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Titolo:
GENOTOXIC EFFECTS OF 2-TRANS-HEXENAL IN HUMAN BUCCAL MUCOSA CELLS IN-VIVO
Autore:
DITTBERNER U; SCHMETZER B; GOLZER P; EISENBRAND G; ZANKL H;
Indirizzi:
UNIV KAISERSLAUTERN,DEPT BIOL,DIV HUMAN GENET & MOL BIOL D-67663 KAISERSLAUTERN GERMANY UNIV KAISERSLAUTERN,DEPT BIOL,DIV HUMAN GENET & MOL BIOL D-67663 KAISERSLAUTERN GERMANY UNIV KAISERSLAUTERN,DEPT CHEM,DIV FOOD CHEM & ENVIRONM TOXICOL D-67663 KAISERSLAUTERN GERMANY
Titolo Testata:
Mutation research. Genetic toxicology and environmental mutagenesis
fascicolo: 1-2, volume: 390, anno: 1997,
pagine: 161 - 165
SICI:
1383-5718(1997)390:1-2<161:GEO2IH>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICRONUCLEUS TEST; EXFOLIATED CELLS; EPITHELIAL-CELLS; TOBACCO CHEWERS; CYCLIC ADDUCTS; ALDEHYDES; RISK; DEOXYGUANOSINE; MUTAGENICITY; INDUCTION;
Keywords:
2-TRANS-HEXENAL; MICRONUCLEI IN VIVO; HUMAN; BUCCAL MUCOSA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
U. Dittberner et al., "GENOTOXIC EFFECTS OF 2-TRANS-HEXENAL IN HUMAN BUCCAL MUCOSA CELLS IN-VIVO", Mutation research. Genetic toxicology and environmental mutagenesis, 390(1-2), 1997, pp. 161-165

Abstract

In 7 non-smoking healthy volunteers, the number of micronuclei (MN) was determined in exfoliated buccal mucosa cells before and after rinsing the mouth with an aqueous 10 ppm solution of 2-trans-hexenal during3 consecutive days. All individuals showed at least a doubling of theMN frequency during one of the next 4 days. An increase of the mean group MN frequency was observed on the fourth day, becoming significantbetween the sixth and the seventh day. During the next 2 days, the MNfrequency dropped down to nearly the control level. In a second study, 7 other volunteers were examined before and after eating 3-6 bananasper day over a period of 3 days. The bananas contained about 35 ppm of hexenal. Six of the 7 individuals showed at least a doubling of the MN frequency during one of the next 6 days. An increase in the mean MNcounts was also observed, but the difference to the control value became non-significant during the test period. The results show for the first time that the flavoring constituent 2-trans-hexenal, which is present in many human foods exerts genotoxic effects on human buccal mucosa cells in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 05:06:37