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Titolo:
ELEVATED CONFORMATIONAL RIGIDITY IN DIPEPTIDES INCORPORATING PIPERAZIC ACID-DERIVATIVES
Autore:
XI N; ALEMANY LB; CIUFOLINI MA;
Indirizzi:
RICE UNIV,DEPT CHEM,MS 60,6100 MAIN ST HOUSTON TX 77005 RICE UNIV,DEPT CHEM HOUSTON TX 77005
Titolo Testata:
Journal of the American Chemical Society
fascicolo: 1, volume: 120, anno: 1998,
pagine: 80 - 86
SICI:
0002-7863(1998)120:1<80:ECRIDI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-HYDRAZINO ACIDS; STEREOSELECTIVE AMINATION; ACTINOMADURA-LUZONENSIS; ASYMMETRIC-SYNTHESIS; 4-HELIX BUNDLE; PROTEIN; AMINO; PEPTIDES; DESIGN; BBM-928-A;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
N. Xi et al., "ELEVATED CONFORMATIONAL RIGIDITY IN DIPEPTIDES INCORPORATING PIPERAZIC ACID-DERIVATIVES", Journal of the American Chemical Society, 120(1), 1998, pp. 80-86

Abstract

N-Acyl derivatives of piperazic acids display an unusual degree of conformational rigidity. As a consequence, alpha-N-coupling of a piperazic acid of given configuration (D or L) with an alpha-aminoacyl unit of opposite configuration (L or D) produces a ''heterochiral'' dipeptide that exists in a conformation conducive to the formation of a peptide turn. Piperazic acids and related compounds may thus be regarded as conformationally rigid analogues of proline, and because they are readily available in either antipodal form by synthesis, they should become of great interest in the study of peptide turns.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:05:30