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Titolo:
DIAZEPAM-BINDING INHIBITOR (DBI) IN THE PLASMA OF PEDIATRIC AND ADULTEPILEPTIC PATIENTS
Autore:
FERRARESE C; COGLIATI T; TORTORELLA R; ZUCCA C; BOGLIUN G; BEGHI E; PASSONI D; ZOIA C; BEGNI B; AIROLDI L; ALHO H; FRATTOLA L;
Indirizzi:
UNIV MILAN,OSPED SAN GERARDO,DEPT NEUROL,VIA DONIZETTI 106 I-20052 MONZA ITALY SCI INST E MEDEA BOSISIO PARINI LECCO ITALY UNIV MILAN,DEPT NEUROL MONZA ITALY UNIV MILAN,DEPT ANAT MONZA ITALY NATL PUBL HLTH INST,DEPT ALCOHOL RES HELSINKI FINLAND
Titolo Testata:
Epilepsy research
fascicolo: 2, volume: 29, anno: 1998,
pagine: 129 - 134
SICI:
0920-1211(1998)29:2<129:DI(ITP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL BENZODIAZEPINE RECEPTORS; HUMAN-LYMPHOCYTES;
Keywords:
EPILEPSY; DIAZEPAM BINDING INHIBITOR; PERIPHERAL BENZODIAZEPINE RECEPTORS; DRUG RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
C. Ferrarese et al., "DIAZEPAM-BINDING INHIBITOR (DBI) IN THE PLASMA OF PEDIATRIC AND ADULTEPILEPTIC PATIENTS", Epilepsy research, 29(2), 1998, pp. 129-134

Abstract

The polypeptide diazepam binding inhibitor (DBI) displays epileptogenic activity by binding to benzodiazepine receptors, We analyzed DBI concentrations in the plasma of pediatric and adult epileptic patients, as a possible peripheral marker in epilepsy. DBI plasma concentrationsare significantly higher (+ 62%, P < 0.001) in adult patients and slightly but significantly higher (+ 15%, P < 0.01) in pediatric patients, compared to age-related controls, Strikingly, plasma DBI is much higher (+ 81%, P < 0.001) in generalized epilepsy in adults and in drug-resistant pediatric and adult patients. Based on these findings, plasmaDBI may be considered as a peripheral biological marker of epilepsy and, in association with lymphocyte benzodiazepine receptor density, ofanticonvulsant drug responsiveness. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:47:54