Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
POTENT EFFECT OF ZINC ACEXAMATE ON BONE COMPONENTS IN THE FEMORAL-METAPHYSEAL TISSUES OF ELDERLY FEMALE RATS
Autore:
YAMAGUCHI M; GAO YH;
Indirizzi:
UNIV SHIZUOKA,GRAD SCH NUTR SCI,LAB ENDOCRINOL & MOL METAB,52-1 YADA SHIZUOKA 422 JAPAN
Titolo Testata:
General pharmacology
fascicolo: 3, volume: 30, anno: 1998,
pagine: 423 - 427
SICI:
0306-3623(1998)30:3<423:PEOZAO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
L-HISTIDINATO ZINC; OSTEOBLASTIC MC3T3-E1 CELLS; WEANLING RATS; BETA; GROWTH; METABOLISM;
Keywords:
ZINC; ZINC ACEXAMATE; BONE FORMATION; AGING; RAT FEMUR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
M. Yamaguchi e Y.H. Gao, "POTENT EFFECT OF ZINC ACEXAMATE ON BONE COMPONENTS IN THE FEMORAL-METAPHYSEAL TISSUES OF ELDERLY FEMALE RATS", General pharmacology, 30(3), 1998, pp. 423-427

Abstract

1. The effect of zinc compounds on bone components in the femoral-metaphyseal tissues from elderly female rats (50 weeks old) was investigated in vitro. Bone tissues were cultured for 24 hr in Dulbecco's modified Eagle medium containing either vehicle or zinc compounds (10(-7) to 10(-5) M). 2. Zinc content, alkaline phosphatase activity, deoxyribonucleic acid (DNA) and calcium contents in the metaphyseal tissues were significantly increased by the presence of zinc sulfate (10(-6) and 10(-5) M), beta-aranyl-L-histidinato zinc (AHZ; 10(-6) and 10(-5) M) and zinc acexamate (10(-7) to 10(-5) M). At 10(-5) M, the effect of zinc acexamate on the increase of bone components was more potent than that of zinc sulfate or AHZ. 3. The effect of zinc acexamate (10(-5) M) on the increase of alkaline phosphatase activity in the metaphyseal tissues was remarkable as compared with that of insulin (10(-8) M), estrogen (10(-9) M), insulin-like growth factor-I (10(-8) M), transforminggrowth factor-beta (10(-10) M), sodium fluoride (10(-3) M), dexamethasone (10(-7) M) and vitamin K-2 (menaquinone-4; 10(-5) M) with an effective concentration. 4. The stimulatory effect of zinc acexamate (10(-5) M) on alkaline phosphatase activity and calcium content in the metaphyseal tissues was completely blocked by the presence of dipicolinate(10(-3) M), a chelator of zinc ion, and of cycloheximide (10(-6) M), an inhibitor of protein synthesis. 5. The present study demonstrates that zinc acexamate has a potent anabolic effect on bone compo nents inthe femoral-metaphyseal tissues from female elderly rats in vitro. The effect of zinc acexamate may be based in part on protein synthesis related to zinc ion in bone cells. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:41:14