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Titolo:
SULCAL VARIABILITY IN THE ALZHEIMERS BRAIN - CORRELATIONS WITH COGNITION
Autore:
MEGA MS; THOMPSON PM; CUMMINGS JL; BACK CL; XU ML; ZOHOORI S; GOLDKORN A; MOUSSAI J; FAIRBANKS L; SMALL GW; TOGA AW;
Indirizzi:
UNIV CALIF LOS ANGELES,SCH MED,DEPT NEUROL,LAB NEUROIMAGING,710 WESTWOOD PLAZA,RM 4-238 LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,SCH MED,DEPT NEUROL,LAB NEUROIMAGING LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,SCH MED,RUSH ALZHEIMERS DIS CTR LOS ANGELES CA90024 UNIV CALIF LOS ANGELES,SCH MED,DEPT PSYCHIAT & BEHAV SCI LOS ANGELES CA 90024 UNIV CALIF LOS ANGELES,SCH MED,CTR AGING LOS ANGELES CA 90024
Titolo Testata:
Neurology
fascicolo: 1, volume: 50, anno: 1998,
pagine: 145 - 151
SICI:
0028-3878(1998)50:1<145:SVITAB>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORAL-LOBE ATROPHY; SENILE DEMENTIA; DISEASE; VOLUMES; AGE; CT; PROGRESSION; TOMOGRAPHY; IMPAIRMENT; DIAGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Mega et al., "SULCAL VARIABILITY IN THE ALZHEIMERS BRAIN - CORRELATIONS WITH COGNITION", Neurology, 50(1), 1998, pp. 145-151

Abstract

We mapped the three dimensional (3D) extents and variability of selected sulci in the Alzheimer's brain and explored the relationship between sulcal pattern and patient's cognitive performance. High-resolutionMRIs of 10 patients with probable Alzheimer's disease (AD) were Linearly transformed into a standard ''normalized'' 3D atlas (known as the Talairach coordinate system) and, on each relevant slice, contours of the left and right Sylvian fissure, anterior and posterior calcarine, callosal, parietooccipital, and cingulate sulci and the floor of the temporal horn of the lateral ventricle were traced. These landmarks were chosen because of their relative invariant location across individuals and because they demarcate functional boundaries relevant in AD. The sulcal contours were resolved into two-dimensional surfaces that cutthrough a brain volume. All 10 patients' sulcal surfaces were averaged to determine their mean spatial locations in the Talairach coordinate system. The 3D spatial extents of each patient's sulci were comparedwith their disease severity based on neuropsychological performance. The 3D sulcal variability, within the ''normalized'' atlas space, ranged from 4.0 mm for the left callosal sulcus to 9.1 mm for the left Sylvian fissure. Significant correlations were found among the spatial extents for the posterior floor of the right temporal horn of the lateral ventricle (r = -0.89, p < 0.001 for vertical extent) and right anterior calcarine sulcus (r = -0.75, p < 0.01 for anterior-posterior extent) with copying ability of the Rey-Osterrieth Complex Figure; the right anterior calcarine also had a significant relationship (r = -0.72, p= 0.02 for anterior-posterior extent) with performance on the Block Design subtest from the Wechsler Adult Intelligence Scale-Revised. Verbal fluency performance measured by the Controlled Oral Word Association Test was significantly related to the left cingulate (r = 0.91, p < 0.001 for anterior-posterior extent, and r = -0.82, p < 0.01 for vertical extent) and right cingulate (r = -0.72, p less than or equal to 0.02 for vertical extent) sulci. This exploratory study is the first to evaluate the relationship between 3D sulcal variability and cognition;our preliminary findings suggest that the 3D pattern of sulci in the AD brain is related to the severity of the disease as reflected by cognitive performance. In the Talairach brain atlas, sulcal variability, within an AD population, approaches 1 cm. This large variability requires correction when functional imaging data are transformed into the Talairach atlas space to ''normalize'' individual morphologic differences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 06:26:21