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Titolo:
CRUCIAL FACTORS REGULATING SITE INTERACTIONS IN RESIN SUPPORTS DETERMINED BY SINGLE BEAD IR
Autore:
YAN B; SUN Q;
Indirizzi:
NOVARTIS PHARMACEUT CORP,59 ROUTE 10 E HANOVER NJ 07936
Titolo Testata:
Journal of organic chemistry
fascicolo: 1, volume: 63, anno: 1998,
pagine: 55 - 58
SICI:
0022-3263(1998)63:1<55:CFRSII>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMBINATORIAL ORGANIC-SYNTHESIS; SMALL-MOLECULE LIBRARIES; SOLID-PHASE REACTIONS; FTIR MICROSPECTROSCOPY; POLYMER SUPPORTS; DRUG DISCOVERY; STRATEGIES; COMPLEXES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
B. Yan e Q. Sun, "CRUCIAL FACTORS REGULATING SITE INTERACTIONS IN RESIN SUPPORTS DETERMINED BY SINGLE BEAD IR", Journal of organic chemistry, 63(1), 1998, pp. 55-58

Abstract

Interactions between resin-bond reactive groups were determined by measuring the single bead IR signals sensitive to their association and dissociation. Our results strongly indicate that site separation and site interaction always occur and that they are in a dynamic equilibrium in resins. The highly dynamic nature of the site interaction was demonstrated by the lack of linker-length influence on site interaction. An increased competition for nearby sites or a reduced availability ofthe nearby sites all suppressed site interaction, indicating the importance of the availability of sites. Our results indicated that the less bulky microenvironment, the more reactive functional group, and themore available nearby sites are factors which favor site interaction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 08:25:04