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Titolo:
AGE-INDUCED WHITE-MATTER CHANGES IN THE HUMAN BRAIN - A STEREOLOGICALINVESTIGATION
Autore:
TANG Y; NYENGAARD JR; PAKKENBERG B; GUNDERSEN HJG;
Indirizzi:
AARHUS UNIV,STEREOL RES LAB,UNIV INST PATHOL,UNIV BARTHOLIN BLDG DK-8000 AARHUS DENMARK AARHUS UNIV,UNIV CLIN INTERNAL MED 2,INST EXPT CLIN RES DK-8000 AARHUS DENMARK KOMMUNE HOSP COPENHAGEN,BARTHOLIN INST,NEUROL RES LAB COPENHAGEN DENMARK N SICHUAN MED COLL,DEPT ANAT NANCHONG SICHUAN PEOPLES R CHINA
Titolo Testata:
Neurobiology of aging
fascicolo: 6, volume: 18, anno: 1997,
pagine: 609 - 615
SICI:
0197-4580(1997)18:6<609:AWCITH>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; COMPUTED-TOMOGRAPHY; RISK-FACTORS; AGING BRAIN; MR; ATROPHY; AIDS; SECTIONS; LESIONS; NUMBER;
Keywords:
LENGTH; VOLUME; DIAMETER; MYELINATED FIBERS; WHITE MATTER; HUMAN BRAIN; AGING; STEREOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
Y. Tang et al., "AGE-INDUCED WHITE-MATTER CHANGES IN THE HUMAN BRAIN - A STEREOLOGICALINVESTIGATION", Neurobiology of aging, 18(6), 1997, pp. 609-615

Abstract

In the present pilot study, age-related white matter changes were investigated by the use of design-based stereological methods. In the brains of elderly subjects, the total volume of the white matter and the total volume of the myelinated fibers therein were lower than in thoseof young subjects (15% and 17%, respectively), but the differences were not statistically significant. The rotal length of the myelinated fibers of the white matter in the elderly group of 86,000 km was, statistically, significantly decreased by 27% compared with 118,000 km in the young group. This loss of the total nerve fiber length was accompanied in particular by a decline of the myelinated fibers with a small diameter. The mean diameter of the myelinated fibers in the young groupwas significantly smaller than in the old group, but the relative size distributions of the myelinated fiber diameters between the young and old groups were similar. Our findings show that the atrophy of the human white matter during ageing is probably caused by a loss of myelinated fibers with a small diameter. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:29:23