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Titolo:
PHARMACOLOGICAL CHARACTERIZATION AND DIFFERENTIATION OF NONCHOLINERGIC NUCLEUS BASALIS NEURONS IN-VITRO
Autore:
FORT P; KHATEB A; SERAFIN M; MUHLETHALER M; JONES BE;
Indirizzi:
DEPT EXPT MED,CNRS,ERS 5645,INSERM,U52,8 AVE ROCKEFELLER F-69373 LYONFRANCE CMU,DEPT PHYSIOL CH-1211 GENEVA 4 SWITZERLAND MCGILL UNIV,MONTREAL NEUROL INST,DEPT NEUROL & NEUROSURG MONTREAL PQ H3A 2B4 CANADA
Titolo Testata:
NeuroReport
fascicolo: 1, volume: 9, anno: 1998,
pagine: 61 - 65
SICI:
0959-4965(1998)9:1<61:PCADON>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG BRAIN; FOREBRAIN NEURONS; IMMUNOHISTOCHEMICAL EVIDENCE; IN-VITRO; RAT; NEOCORTEX; AFFERENTS; INTERNEURONS; MODULATION;
Keywords:
ACETYLCHOLINE; BASAL FOREBRAIN; CORTEX; HISTAMINE; MUSCARINE; NORADRENALINE; SEROTONIN; SLEEP-WAKE STATES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
P. Fort et al., "PHARMACOLOGICAL CHARACTERIZATION AND DIFFERENTIATION OF NONCHOLINERGIC NUCLEUS BASALIS NEURONS IN-VITRO", NeuroReport, 9(1), 1998, pp. 61-65

Abstract

USING intracellular recordings in guinea pig brain slices, the pharmacology of electrophysiologically identified and immunohistochemically confirmed non-cholinergic nucleus basalis neurons was studied to determine their response to the major neurotransmitters of the subcortical afferents to this region. The cells were differentiated into three types: Type A cells (similar to 44%) were depolarized by noradrenaline (NA) and muscarine, Type B cells (similar to 23%) were depolarized by NAbut hyperpolarized by muscarine, and Type C cells (similar to 15%) were hyperpolarized by both agonists. These cell types were also differentially responsive to serotonin (hyperpolarizing B, C) and histamine (depolarizing A, B). Accordingly, the non-cholinergic neurons share certain discharge properties but appear nonetheless to comprise distinct types which respond differentially to the major modulatory neurotransmitters and thus play potentially different roles in cortical modulation across the sleep-wake cycle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:21:24