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Titolo:
RETINOBLASTOMA PROTEIN EXPRESSION FACILITATES CHROMATIN REMODELING ATTHE HLA-DRA PROMOTER
Autore:
OSBORNE A; TSCHICKARDT M; BLANCK G;
Indirizzi:
UNIV S FLORIDA,COLL MED,DEPT BIOCHEM & MOL BIOL,MDC BOX 7,12901 BRUCEB DOWNS BLVD TAMPA FL 33612 UNIV S FLORIDA,COLL MED,DEPT BIOCHEM & MOL BIOL TAMPA FL 33612 UNIV S FLORIDA,COLL MED,INST BIOMOL SCI TAMPA FL 33612
Titolo Testata:
Nucleic acids research
fascicolo: 24, volume: 25, anno: 1997,
pagine: 5095 - 5102
SICI:
0305-1048(1997)25:24<5095:RPEFCR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
II TRANSACTIVATOR CIITA; BARE LYMPHOCYTE SYNDROME; BREAST-CARCINOMA CELLS; IFN-GAMMA INDUCTION; BINDING-PROTEIN; TRANSCRIPTIONAL ACTIVATORS; GENE-TRANSCRIPTION; INTERFERON-GAMMA; INVARIANT CHAIN; MESSENGER-RNAS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
A. Osborne et al., "RETINOBLASTOMA PROTEIN EXPRESSION FACILITATES CHROMATIN REMODELING ATTHE HLA-DRA PROMOTER", Nucleic acids research, 25(24), 1997, pp. 5095-5102

Abstract

The major histocompatibility complex (MHC) class II genes encode a series of heterodimeric cell surface glycoproteins that bind peptide antigen, The MHC class II/peptide complex is bound by the T-cell receptorof CD4(+) T cells, thereby stimulating an immune response, The MHC class IT genes are coordinately regulated by conserved promoter elementsand are inducible by IFN-gamma, Furthermore, IFN-gamma induction of the MHC class II genes in solid human tumor lines requires retinoblastoma protein (Rb). In vivo footprinting analyses of the HLA-DRA gene, which encodes the heavy chain subunit of the human MHC class II molecule, HLA-DR, revealed that Rb facilitates occupancy of multiple HLA-DRA promoter elements. Detecting the effect of Rb on HLA-DRA promoter occupancy in vivo required IFN-gamma treatment, However, use of a variationon the in vivo footprinting technique, nuclei footprinting, which assays for promoter occupancy in isolated nuclei, revealed that expression of Rb facilitates promoter occupancy even in the absence of IFN-gamma. These results indicate that expression of Rb leads to modification of the chromatin environment of the HLA-DRA promoter independently of transcription.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:41:33