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Titolo:
THERMAL PRECONDITIONING BEFORE RAT ARTERIAL BALLOON INJURY - LIMITATION OF INJURY AND SUSTAINED REDUCTION OF INTIMAL THICKENING
Autore:
NESCHIS DG; SAFFORD SD; RAGHUNATH PN; LANGER DJ; DAVID ML; HANNA AK; TOMASZEWSKI JE; KARIKO K; BARNATHAN ES; GOLDEN MA;
Indirizzi:
HOSP UNIV PENN,DEPT SURG,3400 SPRUCE ST,4 SILVERSTEIN PAVIL PHILADELPHIA PA 19104 UNIV PENN,MED CTR,DEPT SURG PHILADELPHIA PA 19104 UNIV PENN,MED CTR,DEPT MED PHILADELPHIA PA 19104 UNIV PENN,MED CTR,DEPT PATHOL PHILADELPHIA PA 19104
Titolo Testata:
Arteriosclerosis, thrombosis, and vascular biology
fascicolo: 1, volume: 18, anno: 1998,
pagine: 120 - 126
SICI:
1079-5642(1998)18:1<120:TPBRAB>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEAT-SHOCK PROTEIN; FIBROBLAST GROWTH-FACTOR; WARM ISCHEMIC-INJURY; MUSCLE CELL-PROLIFERATION; CORONARY-ARTERY; DIRECTIONAL ATHERECTOMY; ANGIOPLASTY; EXPRESSION; DISEASE; STRESS;
Keywords:
HEAT SHOCK PROTEINS; ARTERIES; RESTENOSIS; SMOOTH MUSCLE; BALLOON;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
D.G. Neschis et al., "THERMAL PRECONDITIONING BEFORE RAT ARTERIAL BALLOON INJURY - LIMITATION OF INJURY AND SUSTAINED REDUCTION OF INTIMAL THICKENING", Arteriosclerosis, thrombosis, and vascular biology, 18(1), 1998, pp. 120-126

Abstract

Heat shock proteins (HSPs) are a family of highly conserved proteins,essential to cell survival, that are induced during times of physiological stress. These proteins, when induced, can provide tolerance to subsequent injury. Several studies have documented that HSPs play an important role in the response of vascular cells to injury or stress. Whether the vasculature itself can be effectively preconditioned before arterial injury is unknown. Vascular HSP induction by whole-body hyperthermia (WBH) was evaluated with regard to its effects on the vascularresponse to balloon injury. WBH treatment of Sprague-Dawley rats (colonic temperatures of 41 to 42 degrees C for 15 minutes) resulted in maximal arterial HSP expression within 8 to 12 hours. Rats (male, 300 g,n=59) were randomly assigned to undergo either WBH or no treatment 8 hours before standard carotid balloon injury. At 14 (n=26) and 90 (n=21) days after balloon injury, histomorphometric analysis revealed a significant limitation of intimal accumulation ill preconditioned arteries as compared to controls (intimal/medial area ratios+/-SEM: 14 days.0.57+/-0.07 versus 0.86+/-0.08, P=0.01; 90 days, 0.78+/-0.12 versus 1.19+/-0.14, P<0.05). The menial cell proliferation index at 4 days (n=12) was significantly reduced in the treated group as well (3.6+/-0.9%versus 7.2+/-1.3%, P<0.05). Conversely, the mean total cell number inthe media of heated arteries was higher (393+/-20 venus 328+/-17, P<0.05). Vascular preconditioning with brief WBH induces a heat shock response in the arterial wall that is associated with a significant and sustained reduction in intimal accumulation. This effect appears to be due in part to preservation of medial cell integrity and limitation ofthe proliferative response. These results suggest that thermal preconditioning of vascular tissue may be an effective strategy to improve long-term results after revascularization procedures.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/10/20 alle ore 12:26:29