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Titolo:
THE EPIDEMIOLOGY OF RESISTANCE TO OFLOXACIN AND OXACILLIN AMONG CLINICAL COAGULASE-NEGATIVE STAPHYLOCOCCAL ISOLATES - ANALYSIS OF RISK-FACTORS AND STRAIN TYPES
Autore:
PEGUES DA; COLBY C; HIBBERD PL; COHEN LG; AUSUBEL FM; CALDERWOOD SB; HOOPER DC;
Indirizzi:
HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT PHARM,INFECT DIS DIV,INFECT CONTROL UNIT BOSTON MA 02114 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT PHARM,INFECT DIS DIV,INFECT CONTROL UNIT BOSTON MA 02114 HARVARD UNIV,MASSACHUSETTS GEN HOSP,SCH MED,DEPT BIOL MOL BOSTON MA 02114 NORTHEASTERN UNIV,BOUVE COLL PHARM,DEPT PHARM PRACTICE BOSTON MA 02115
Titolo Testata:
Clinical infectious diseases
fascicolo: 1, volume: 26, anno: 1998,
pagine: 72 - 79
SICI:
1058-4838(1998)26:1<72:TEORTO>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHICILLIN-RESISTANT; CIPROFLOXACIN-RESISTANT; QUINOLONE RESISTANCE; DNA GYRASE; UNITED-STATES; AUREUS; EPIDERMIDIS; FLUOROQUINOLONES; MUTATIONS; EMERGENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
D.A. Pegues et al., "THE EPIDEMIOLOGY OF RESISTANCE TO OFLOXACIN AND OXACILLIN AMONG CLINICAL COAGULASE-NEGATIVE STAPHYLOCOCCAL ISOLATES - ANALYSIS OF RISK-FACTORS AND STRAIN TYPES", Clinical infectious diseases, 26(1), 1998, pp. 72-79

Abstract

Coagulase-negative staphylococci are important nosocomial pathogens that increasingly are resistant to oxacillin and fluoroquinolones. To determine predictors of acquisition of oxacillin and ofloxacin resistance, we prospectively identified 150 patients from whose clinical specimens coagulase-negative staphylococci were isolated that differed in susceptibility to oxacillin and ofloxacin. In multivariate analysis, isolation of ofloxacin-resistant coagulase-negative staphylococci was associated with receipt of aminoglycosides (odds ratio [OR] = 8.45; 95% confidence interval [CI] = 2.10-34.1; P = .001) and fluoroquinolones (OR = 11.50; 95% CI = 4.15-31.6; P < .001) within 30 days; oxacillin resistance was associated with prior receipt of beta-lactam agents (OR =5.99; 95% CI = 2.91-12.3; P < .001), Among oxacillin-resistant strains, there was heterogeneity of pulsed-field gel electrophoresis (PFGE) types, and no type was common between ofloxacin-resistant and ofloxacin-susceptible strains. Thus ofloxacin resistance may have emerged de novo among diverse oxacillin-resistant strains following the selection pressures of antimicrobial therapy, In contrast, 50% of patients with oxacillin susceptible/ofloxacin-resistant strains had one of two PFGE types, a finding suggesting that person-to-person transmission resulted in the dissemination of some of these strains.

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Documento generato il 05/04/20 alle ore 22:09:29