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Titolo:
DOPAMINERGIC MODULATION OF NMDA-INDUCED WHOLE-CELL CURRENTS IN NEOSTRIATAL NEURONS IN SLICES - CONTRIBUTION OF CALCIUM CONDUCTANCES
Autore:
CEPEDA C; COLWELL CS; ITRI JN; CHANDLER SH; LEVINE MS;
Indirizzi:
UNIV CALIF LOS ANGELES,MENTAL RETARDAT RES CTR,760 WESTWOOD PLAZA LOSANGELES CA 90024 UNIV CALIF LOS ANGELES,DEPT PHYSIOL SCI LOS ANGELES CA 90024
Titolo Testata:
Journal of neurophysiology
fascicolo: 1, volume: 79, anno: 1998,
pagine: 82 - 94
SICI:
0022-3077(1998)79:1<82:DMONWC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY SYNAPTIC TRANSMISSION; RAT STRIATAL NEURONS; RETINAL HORIZONTAL CELLS; PATCH-CLAMP RECORDINGS; METHYL-D-ASPARTATE; PROTEIN KINASE-A; NUCLEUS-ACCUMBENS; AMINO-ACIDS; IN-VITRO; NEUROMODULATORY ACTIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
95
Recensione:
Indirizzi per estratti:
Citazione:
C. Cepeda et al., "DOPAMINERGIC MODULATION OF NMDA-INDUCED WHOLE-CELL CURRENTS IN NEOSTRIATAL NEURONS IN SLICES - CONTRIBUTION OF CALCIUM CONDUCTANCES", Journal of neurophysiology, 79(1), 1998, pp. 82-94

Abstract

The present experiments were designed to examine dopamine (DA) modulation of whole cell currents mediated by activation of N-methyl-D-aspartate (NMDA) receptors in visualized neostriatal neurons in slices. First, we assessed the ability of DA, D-1 and D-2 receptor agonists to modulate membrane currents induced by activation of NMDA receptors. The results of these experiments demonstrated that DA potentiated NMDA-induced currents in medium-sized neostriatal neurons. Potentiation of NMDA currents occurred at three different holding potentials, although itwas more pronounced at -30 mV. It was mediated by D-1 receptors, because it was mimicked by D-1 agonists and blocked by exposure to a D-2 antagonist. Activation of D-2 receptors produced inconsistent effects on NMDA-induced membrane currents. Either decreases, increases, or no effects on NMDA currents occurred. Second, vie examined the contributions of intrinsic, voltage-dependent conductances to DA potentiation of NMDA currents. Blockade of K+ conductances did not prevent DA enhancement of NMDA currents. However, voltage-activated Ca2+ conductances provided a major contribution to DA modulation. The dihydropyridine L-type Ca2+ channel blockers, nifedipine, and methoxyverapamil (D-600), markedly reduced but did not totally eliminate the ability of DA to modulate NMDA currents. The D-1 receptor agonist SKF 38393 also enhanced Ba2+ currents in neostriatal neurons. Together, these findings provide evidence for a complex interplay between DA, NMDA receptor activation and dihydropyridine-sensitive Ca2+ conductances in controlling responsiveness of neostriatal medium-sized neurons.

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Documento generato il 20/10/20 alle ore 04:59:41