Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CHEMOTHERAPY OF NON-SMALL-CELL LUNG-CANCER - A PROSPECTIVELY RANDOMIZED STUDY OF CISPLATIN-ETOPOSIDE VERSUS CISPLATIN-MITOMYCIN-VINBLASTINE
Autore:
POLYZOS A; TSAVARIS N; VESLEMES M; DARDOUFAS K; DOSIOS T; KOSMAS C;
Indirizzi:
UNIV ATHENS,SCH MED,LAIKON HOSP,DEPT PROPEDEUT MED 1 GR-11527 ATHENS GREECE
Titolo Testata:
Journal of chemotherapy
fascicolo: 2, volume: 9, anno: 1997,
pagine: 102 - 105
SICI:
1120-009X(1997)9:2<102:CONL-A>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMBINATION CHEMOTHERAPY; TRIAL; CARCINOMA; VINDESINE; REGIMENS;
Keywords:
NON SMALL CELL LUNG CANCER; ETOPOSIDE; CISPLATIN; MITOMYCIN; VINBLASTINE; LUNG CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
A. Polyzos et al., "CHEMOTHERAPY OF NON-SMALL-CELL LUNG-CANCER - A PROSPECTIVELY RANDOMIZED STUDY OF CISPLATIN-ETOPOSIDE VERSUS CISPLATIN-MITOMYCIN-VINBLASTINE", Journal of chemotherapy, 9(2), 1997, pp. 102-105

Abstract

Based on preclinical studies showing synergism between cisplatin and etoposide, we randomized patients with non small cell lung cancer (NSCLC) to receive either the above combination (cisplatin 100mg/m(2) day 1, etoposide 130mg/m(2) days 1-3) or the combination of cisplatin-mitomycin-e and vinca drugs (MVP) (cisplatin 100mg/m(2), vinblastine 6mg/m(2), mitomycin 10mg/m(2) day 1), a regimen with a steady response rate. Partial responses were achieved in 12/44 (27%) of the cisplatin-etoposide group and in 11/43 (26%) of the MVR group. No difference in median survival could be demonstrated between the two groups (36 weeks versus 38 weeks). Myelotoxicity and alopecia were more severe in the cisplatin-etoposide group. Compared to international experience both regimens exhibited a relatively low response rate. It seems that for NSCLC new agents are required.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 15:44:05