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Titolo:
LAT - THE ZAP-70 TYROSINE KINASE SUBSTRATE THAT LINKS T-CELL RECEPTORTO CELLULAR ACTIVATION
Autore:
ZHANG WG; SLOANLANCASTER J; KITCHEN J; TRIBLE RP; SAMELSON LE;
Indirizzi:
NICHHD,SECT LYMPHOCYTE SIGNALLING,CELL BIOL & METAB BRANCH,NIH BETHESDA MD 20892
Titolo Testata:
Cell
fascicolo: 1, volume: 92, anno: 1998,
pagine: 83 - 92
SICI:
0092-8674(1998)92:1<83:L-TZTK>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIGEN RECEPTOR; SIGNAL-TRANSDUCTION; PHOSPHATIDYLINOSITOL 3-KINASE; ADAPTER PROTEIN; SH2 DOMAINS; GRB2; PHOSPHORYLATION; SLP-76; PHOSPHOPROTEIN; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
W.G. Zhang et al., "LAT - THE ZAP-70 TYROSINE KINASE SUBSTRATE THAT LINKS T-CELL RECEPTORTO CELLULAR ACTIVATION", Cell, 92(1), 1998, pp. 83-92

Abstract

Despite extensive study, several of the major components involved in T cell receptor-mediated signaling remain unidentified. Here we reportthe cloning of the cDNA for a highly tyrosine-phosphorylated 36-38 kDa protein, previously characterized by its association with Grb2, phospholipase C-gamma 1, and the p85 subunit of phosphoinositide 3-kinase. Deduced amino acid sequence identifies a novel integral membrane protein containing multiple potential tyrosine phosphorylation sites. We show that this protein is phosphorylated by ZAP-70/Syk protein tyrosinekinases leading to recruitment of multiple signaling molecules. Its function is demonstrated by inhibition of T cell activation following overexpression of a mutant form lacking critical tyrosine residues. Therefore, we propose to name the molecule LAT-linker for activation of Tcells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 21:45:46