Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NUCLEOSOME POSITIONING BY THE WINGED HELIX TRANSCRIPTION FACTOR HNF3
Autore:
SHIM EY; WOODCOCK C; ZARET KS;
Indirizzi:
BROWN UNIV,DEPT MOL BIOL CELLULAR BIOL & BIOCHEM PROVIDENCE RI 02912 BROWN UNIV,DEPT MOL BIOL CELLULAR BIOL & BIOCHEM PROVIDENCE RI 02912 UNIV MASSACHUSETTS,DEPT BIOL AMHERST MA 01003
Titolo Testata:
Genes & development
fascicolo: 1, volume: 12, anno: 1998,
pagine: 5 - 10
SICI:
0890-9369(1998)12:1<5:NPBTWH>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR VIRUS PROMOTER; SACCHAROMYCES-CEREVISIAE; CHROMATIN STRUCTURE; CRYSTAL-STRUCTURE; LINKER HISTONES; BINDING-SITE; DNA; ENHANCER; GENE; DISRUPTION;
Keywords:
NUCLEOSOME; WINGED HELIX FACTOR; HNF3; ENHANCER; CHROMATIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
E.Y. Shim et al., "NUCLEOSOME POSITIONING BY THE WINGED HELIX TRANSCRIPTION FACTOR HNF3", Genes & development, 12(1), 1998, pp. 5-10

Abstract

Nucleosome positioning at genetic regulatory sequences is not well understood. The transcriptional enhancer of the mouse serum albumin geneis active in liver, where regulatory factors occupy their target sites on three nucleosome-like particles designated N1, N2, and N3. The winged helix transcription factor HNF3 binds to two sites near the center of the N1 particle. We created dinucleosome templates using the albumin enhancer sequence and found that site-specific binding of HNF3 protein resulted in nucleosome positioning in vitro similar to that seen in liver nuclei. Thus, binding of a transcription factor can position an underlying nucleosome core.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 20:00:55