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Titolo:
MANIC-DEPRESSIVE ILLNESS AND TYROSINE-HYDROXYLASE GENE - LINKAGE HETEROGENEITY AND ASSOCIATION
Autore:
MALAFOSSE A; LEBOYER M; DAMATO T; AMADEO S; ABBAR M; CAMPION D; CANSEIL O; CASTELNAU D; GHEYSEN F; GRANGER B; HENRIKSON B; POIRIER MF; SABATE O; SAMOLYK D; FEINGOLD J; MALLET J;
Indirizzi:
HUG,DIV NEUROPSYCHIAT GENEVA SWITZERLAND HOP LA PITIE SALPETRIERE,CNRS,UMR 9923 PARIS FRANCE HOP LA PITIE SALPETRIERE,SERV PSYCHIAT ADULTE PARIS FRANCE HOP LA PITIE SALPETRIERE,CNRS,URA 1957,LAB RECH PERSONNAL & CONDUITESADAPTAT PARIS FRANCE CHU NANTES,SERV PSYCHIAT ADULTE F-44035 NANTES 01 FRANCE CHU MONTPELLIER,SERV PSYCHIAT ADULTE MONTPELLIER FRANCE CHS,SERV PSYCHIAT ADULTE ROUEN FRANCE HOP ST ANNE,SERV PSYCHIAT ADULTE F-75674 PARIS FRANCE CHU CAEN,SERV PSYCHIAT ADULTE F-14000 CAEN FRANCE CHU NECKER,SERV PSYCHIAT ADULTE F-75015 PARIS FRANCE INSERM,U155 PARIS FRANCE
Titolo Testata:
Neurobiology of disease
fascicolo: 5, volume: 4, anno: 1997,
pagine: 337 - 349
SICI:
0969-9961(1997)4:5<337:MIATG->2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR AFFECTIVE-DISORDER; HUMAN INSULIN GENE; PEDIGREE-MEMBER METHOD; OLD ORDER AMISH; DNA MARKERS; CLOSE LINKAGE; POLYMORPHIC REGION; LOCUS; CHROMOSOME-11P; STRATEGIES;
Keywords:
MANIC DEPRESSIVE ILLNESS; TYROSINE HYDROXYLASE; LINKAGE; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
A. Malafosse et al., "MANIC-DEPRESSIVE ILLNESS AND TYROSINE-HYDROXYLASE GENE - LINKAGE HETEROGENEITY AND ASSOCIATION", Neurobiology of disease, 4(5), 1997, pp. 337-349

Abstract

Several studies have implicated the tyrosine hydroxylase (TH) locus within the 11p15 region in susceptibility to manic depressive illness (MDI), This possibility was further investigated by both parametric (led score) and nonparametric (affected-pedigree-member and a case-control study) methods of analysis in 11 French MDI families and in a sampleof 200 unrelated subjects. Both types of analyses corroborate the implication of this locus, and positive lod scores were obtained in two families, which most likely reflects genetic heterogeneity. Statisticalanalyses were also performed including available data from published reports. These analyses, which allowed for genetic heterogeneity, substantiated our findings. The combined maximum lod score for all the families studied was 3.68 at theta = 0.00 (number of families: 36) assuming heterogeneity (alpha = 15%, P = 0.01). Taken together these resultsconverge to suggest that the risk factors for MDI lie in the 11p15 region with TH being the most likely candidate gene. (C) 1997 Academic Press.

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Documento generato il 06/04/20 alle ore 21:43:00