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Titolo:
NUCLEOTIDE-SEQUENCE, GENOME ORGANIZATION, AND TRANSCRIPTION MAP OF BOVINE ADENOVIRUS TYPE-3
Autore:
REDDY PS; IDAMAKANTI N; ZAKHARTCHOUK AN; BAXI MK; LEE JB; PYNE C; BABIUK LA; TIKOO SK;
Indirizzi:
UNIV SASKATCHEWAN,VET INFECT DIS ORG,VIROL GRP,120 VET RD SASKATOON SK S7N 5E3 CANADA UNIV SASKATCHEWAN,VET INFECT DIS ORG,VIROL GRP SASKATOON SK S7N 5E3 CANADA
Titolo Testata:
Journal of virology
fascicolo: 2, volume: 72, anno: 1998,
pagine: 1394 - 1402
SICI:
0022-538X(1998)72:2<1394:NGOATM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-BINDING PROTEIN; MAJOR LATE PROMOTER; OVINE ADENOVIRUS; PHYLOGENETIC-RELATIONSHIPS; TRIPARTITE LEADER; CRYSTAL-STRUCTURE; MESSENGER-RNA; REGION E3; VIRION; LOCATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
76
Recensione:
Indirizzi per estratti:
Citazione:
P.S. Reddy et al., "NUCLEOTIDE-SEQUENCE, GENOME ORGANIZATION, AND TRANSCRIPTION MAP OF BOVINE ADENOVIRUS TYPE-3", Journal of virology, 72(2), 1998, pp. 1394-1402

Abstract

The complete DNA sequence of bovine adenovirus type 3 is reported here, The size of the genome is 34,446 bp in length with a G+C content of54%. All the genes of the early and late regions are present in the expected locations of the genome, However, the late-region genes are organized into seven families, instead of five as they are in human adenovirus type 2, The deduced amino acid sequences of open reading frames(ORFs) in the late regions and early region 2 (E2) and for IVa2 show higher degrees of homology, whereas the predicted amino acid sequencesof ORFs in the E1, E3, and E4 regions and the pIX, fiber, and 33,000-molecular-weight nonstructural proteins show little or no homology with the corresponding proteins of other adenoviruses. In addition, the penton base protein lacks the integrin binding motif, RGD, but has an LDV motif instead of an MDV motif, Interestingly, as in other animal adenoviruses, the virus-associated RNA genes appear to be absent from their usual location, Sequence analysis of cDNA clones representing the early- and late-region genes identified splice acceptor and splice donor sites, polyadenylation signals and polyadenylation sites, and tripartite leader sequences.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 09:26:14