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Titolo:
EFFECTS OF VENTILATION STRATEGIES ON THE EFFICACY OF EXOGENOUS SURFACTANT THERAPY IN A RABBIT MODEL OF ACUTE LUNG INJURY
Autore:
ITO Y; MANWELL SEE; KERR CL; VELDHUIZEN RAW; YAO LJ; BJARNESON D; MCCAIG LA; BARTLETT AJ; LEWIS JF;
Indirizzi:
UNIV WESTERN ONTARIO,LAWSON RES INST,ST JOSEPHS HLTH CTR,DEPT PHYSIOL,268 GROSVENOR ST LONDON ON N6A 4V2 CANADA UNIV WESTERN ONTARIO,LAWSON RES INST,ST JOSEPHS HLTH CTR,DEPT PHYSIOLLONDON ON N6A 4V2 CANADA UNIV WESTERN ONTARIO,LAWSON RES INST,ST JOSEPHS HLTH CTR,DEPT MED LONDON ON N6A 4V2 CANADA
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 1, volume: 157, anno: 1998,
pagine: 149 - 155
SICI:
1073-449X(1998)157:1<149:EOVSOT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; SUBFRACTIONS; REPLACEMENT; LAVAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
Y. Ito et al., "EFFECTS OF VENTILATION STRATEGIES ON THE EFFICACY OF EXOGENOUS SURFACTANT THERAPY IN A RABBIT MODEL OF ACUTE LUNG INJURY", American journal of respiratory and critical care medicine, 157(1), 1998, pp. 149-155

Abstract

We evaluated the effects of various ventilation strategies on the efficacy of exogenous surfactant therapy in lung-injured adult rabbits. Lung injury was induced by repetitive whole-lung saline lavage followedby mechanical ventilation. Three hours after the final lavage, 100 mglipid/kg bovine lipid extract surfactant was instilled. After confirmation of similar responses to exogenous surfactant, animals were then randomized to one of four ventilation groups; (1) Normal tidal volume (VT) (5 cm H2O): VT = 10 ml/kg, respiratory rate (RR) = 30/min, positive end-expiratory pressure (PEEP) = 5 cm H2O; (2) Normal VT (9 cm H2O): VT = 10 ml/kg, RR = 30/min, PEEP = 9 cm H2O; (3) Low VT (5 cm H2O): VT = 5 ml/kg, RR = 60/min, PEEP = 5 cm H2O; (4) Low VT (9 cm H2O): VT = 5 ml/kg, RR = 60/min, PEEP = 9 cm H2O. Animals were ventilated for an additional 3 h and then killed, and lung lavage fluid was analysed. Animals ventilated with the low-VT modes (Low VT [5 cm H2O] and Low VT[9 Cm H2O]) had higher Pa-o2 values (430 +/- 7 mm Hg and 425 +/- 18 mm Hg versus 328 +/- 13 mm Hg) and higher percentages of surfactant in large aggregate forms (83 +/- 2% and 82 +/- 2% versus 67 +/- 4%) at 3 h after treatment than did the Normal VT (5 cm H2O) group (p < 0.05). Increasing the PEEP level was beneficial for a short period after surfactant administration to maintain oxygenation, but did not affect exogenous surfactant aggregate conversion. We speculate that ventilation strategies resulting in low exogenous surfactant aggregate conversion will result in superior physiologic responses to exogenous surfactant.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 06:27:02