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Titolo:
INHIBITION OF ALLERGIC AIRWAY RESPONSES BY INHALED LOW-MOLECULAR-WEIGHT HEPARINS - MOLECULAR-WEIGHT DEPENDENCE
Autore:
MARTINEZSALAS J; MENDELSSOHN R; ABRAHAM WM; HSIAO B; AHMED T;
Indirizzi:
UNIV MIAMI,DIV PULM DIS,MT SINAI MED CTR,SCH MED,4300 ALTON RD MIAMI BEACH FL 33140 UNIV MIAMI,DIV PULM DIS,MT SINAI MED CTR,SCH MED MIAMI BEACH FL 33140
Titolo Testata:
Journal of applied physiology
fascicolo: 1, volume: 84, anno: 1998,
pagine: 222 - 228
SICI:
8750-7587(1998)84:1<222:IOAARB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXERCISE-INDUCED ASTHMA; ANTIGEN-INDUCED AIRWAY; MAST-CELLS; SULFATE CONTENT; HETEROGENEITY; RELEASE; SHEEP;
Keywords:
AIRWAY HYPERRESPONSIVENESS; MAST CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
J. Martinezsalas et al., "INHIBITION OF ALLERGIC AIRWAY RESPONSES BY INHALED LOW-MOLECULAR-WEIGHT HEPARINS - MOLECULAR-WEIGHT DEPENDENCE", Journal of applied physiology, 84(1), 1998, pp. 222-228

Abstract

Inhaled heparin prevents antigen-induced bronchoconstriction and inhibits anti-immunoglobulin E-mediated mast cell degranulation. We hypothesized that the antiallergic action of heparin may be molecular weightdependent. Therefore, we studied the effects of three different low-molecular-weight fractions of heparin [medium-, low-, and ultralow-molecular-weight heparin (MMWH, LMWH, ULMWH, respectively)] on the antigen-induced acute bronchoconstrictor response (ABR) and airway hyperresponsiveness (AHR) in allergic sheep. Specific lung resistance was measured in 22 sheep before and after airway challenge with Ascaris suum antigen, without and after pretreatment with inhaled fractionated heparins at doses of 0.31-5.0 mg/kg. Airway responsiveness was estimated before and 2 h postantigen as the cumulative provocating dose of carbacholin breath units that increased specific lung resistance by 400%. All fractionated heparins caused a dose-dependent inhibition of ABR and AHR. ULMWH was the most effective fraction, with the inhibitory dose causing 50% protection (ID50) against ABR of 0.5 mg/kg, whereas ID50 values of LMWH and MMWH were 1.25 and 1.8 mg/kg, respectively. ULMWH was also the most effective fraction in attenuating AHR; the ID50 values for ULMWH, LMWH, and MMWH were 0.5, 2.5, and 4.7 mg/kg, respectively. These data suggest that 1) fractionated low-molecular-weight heparins attenuate antigen-induced ABR and AHR; 2) there is an inverse relationship between the antiallergic activity of heparin fractions and molecular weight; and 3) ULMWH is the most effective fraction preventing allergic bronchoconstriction and airway hyperresponsiveness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 09:41:13