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Titolo:
STOP-FLOW STUDIES OF DISTRIBUTION OF FILTRATION IN RAT LUNGS
Autore:
LIN W; JACOBS E; SCHAPIRA RM; PRESBERG K; EFFROS RM;
Indirizzi:
9200 WISCONSIN AVE MILWAUKEE WI 53226 MED COLL WISCONSIN,DEPT MED,DIV PULM & CRIT CARE MED MILWAUKEE WI 53226 ZABLOCKI VET AFFAIRS MED CTR MILWAUKEE WI 53295
Titolo Testata:
Journal of applied physiology
fascicolo: 1, volume: 84, anno: 1998,
pagine: 47 - 52
SICI:
8750-7587(1998)84:1<47:SSODOF>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
REFLECTION COEFFICIENT; SURFACE-AREA; DOG LUNGS; EDEMA; DYE;
Keywords:
PULMONARY EDEMA; PULMONARY VASCULATURE; REFLECTION COEFFICIENTS; ENDOTHELIAL UPTAKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
W. Lin et al., "STOP-FLOW STUDIES OF DISTRIBUTION OF FILTRATION IN RAT LUNGS", Journal of applied physiology, 84(1), 1998, pp. 47-52

Abstract

The stop-flow approach was used to investigate where filtration occurs in the pulmonary vasculature after elevation of left atrial pressureand aspiration of HCl. Rat lungs were perfused for 11 min at zero left atrial pressures, and then flow was stopped for 10 min and left atrial pressures were increased to 20 cmH(2)O. Thereafter, (HOH)-H-3 was instilled into the air spaces, and the pulmonary vasculature was flushed by perfusing it from the pulmonary artery to left atrium (anterograde flush) or in the opposite direction (retrograde flush). Increases influorescein isothiocyanate (FITC)-dextran (molecular weight 2.000,000) indicated filtration, and these preceded increases in (HOH)-H-3 after anterograde but not retrograde flushes. This suggests that some filtration occurred through vessels that were relatively venous compared with those through which (HOH)-H-3 exchange had occurred. Filtration increased fivefold after instillation of 0.1 N HCl in isotonic saline into the air spaces before perfusion. Increases in Evans blue-labeled albumin concentrations were <40% those of FITC-dextran, indicating loss from the vasculature, but increases in unlabeled albumin and FITC-albumin were comparable.

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Documento generato il 25/09/20 alle ore 07:08:54