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Titolo:
TREATMENT FOR INFERTILITY AND RISK OF INVASIVE EPITHELIAL OVARIAN-CANCER
Autore:
PARAZZINI F; NEGRI E; LAVECCHIA C; MORONI S; FRANCESCHI S; CROSIGNANI PG;
Indirizzi:
IST RIC FARMACOL MARIO NEGRI,VIA ERITREA 62 I-20157 MILAN ITALY UNIV MILAN,CLIN OSTETR GINECOL 1 I-20129 MILAN ITALY IST NAZL TUMORI,DIV ONCOL GINECOL MILAN ITALY UNIV MILAN,IST STAT MED & BIOMETRIA I-20133 MILAN ITALY CTR RIFERIMENTO ONCOL I-33081 AVIANO PORDENONE ITALY
Titolo Testata:
Human reproduction
fascicolo: 10, volume: 12, anno: 1997,
pagine: 2159 - 2161
SICI:
0268-1161(1997)12:10<2159:TFIARO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
INCESSANT OVULATION; WOMEN; BREAST; COHORT; TUMORS;
Keywords:
EPIDEMIOLOGY; INFERTILITY DRUGS; OVARIAN CANCER; RISK FACTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
F. Parazzini et al., "TREATMENT FOR INFERTILITY AND RISK OF INVASIVE EPITHELIAL OVARIAN-CANCER", Human reproduction, 12(10), 1997, pp. 2159-2161

Abstract

The relationship between the use of fertility drugs and the risk of ovarian cancer was analysed using data from an Italian case-control study. The study comprised 971 women below the age of 75 years with histologically confirmed invasive epithelial ovarian cancer diagnosed within the year before the interview. The controls were 2758 women admittedto the same network of hospitals where the cases of ovarian cancer had been identified. Five cases (0.5%) and 11 controls (0.4%) reported use of fertility drugs. In comparison with women who had never used fertility drugs, the multivariate odds ratio (OR) for women who had takenfertility drugs was 1.1 [95% confidence interval (CI) 0.4-3.3]. The OR were 0.7 (95% CI 0.1-7.9) and 1.0 (95% CI 0.2-3.8) for women who hadused fertility drugs for <6 and greater than or equal to 6 cycles respectively. Considering the 14 cases and 45 controls reporting difficulty in conception, the risk of ovarian cancer was 0.5 (95% CI 0.1-3.6) for women who reported use of fertility drugs. Considering nulliparouswomen only, the estimated OR of ovarian cancer for any fertility druguse was 0.6 (95% CI 0.1-3.5). Although the present results have limitations in terms of statistical power and available information, they provide reassuring evidence of the absence of a strong association between fertility drugs and subsequent risk of developing epithelial ovarian cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:27:31