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Titolo:
STIMULATION OF HIV-1-NEUTRALIZING ANTIBODIES IN SIMIAN HIV-IIIB-INFECTED MACAQUES
Autore:
MULLER S; MARGOLIN DH; NARA PL; ALVORD WG; KOHLER H;
Indirizzi:
IMMPHERON INC,5235 ATHENS BOONESBORO RD LEXINGTON KY 40509 BETH ISRAEL DEACONESS MED CTR BOSTON MA 02215 NCI FREDERICK MD 21702 UNIV KENTUCKY LEXINGTON KY 40536
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 1, volume: 95, anno: 1998,
pagine: 276 - 281
SICI:
0027-8424(1998)95:1<276:SOHAIS>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-GP120 ANTIBODIES; IMMUNE-RESPONSE; SPECIFICITY; INDIVIDUALS; AIDS;
Keywords:
AIDS; RHESUS MACAQUE; VIRUS NEUTRALIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
S. Muller et al., "STIMULATION OF HIV-1-NEUTRALIZING ANTIBODIES IN SIMIAN HIV-IIIB-INFECTED MACAQUES", Proceedings of the National Academy of Sciences of the United Statesof America, 95(1), 1998, pp. 276-281

Abstract

Previously we have discovered a public idiotope, designated 1F7, thatis expressed on antibodies against HIV type 1 (HIV-1) in human and nonhuman primates, To test the potential of mouse monoclonal antibody (mAb) 1F7 as a therapeutic anti-clonotypic antibody in HIV-1-infected patients, we used the simian HIV-IIIB macaque infection model, which mimics several immunological and pathological characteristics of HIV-1 infection in humans, Four healthy simian HIV-infected rhesus monkeys (Macaca mulatta) expressing the 1F7 marker on anti-gp120 antibodies were selected for this study, Three monkeys of this group were immunized several times with the murine mAb 1F7 i.v., and one monkey received as control an isotype-matched antibody, TEPC183, No serious side effect orallergic reaction was encountered, Blood collected before and during the immunization and over several months afterward were analyzed for neutralizing antibodies, Significant increases in breadth and potency of HIV-1-neutralizing antibody titers to one or more virus strains weredetected in all three of the 1F7-immunized monkeys, but not in the control monkey immunized with TEPC183, These results show that an antibody, recognizing a public idiotope associated with anti-HIV-1 antibodies can function in chronically infected primates as an anti-clonotypic immunogen to boost antibodies that neutralize homologous and heterologous virus strains, This study represents a first step toward the preclinical evaluation of 1F7 as a therapeutic AIDS vaccine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 09:13:42