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Titolo:
BCR-ABL ACCELERATES C2-CERAMIDE-INDUCED APOPTOSIS
Autore:
MAGUERSATTA V; BURL S; LIU L; DAMEN J; CHAHINE H; KRYSTAL G; EAVES A; EAVES C;
Indirizzi:
BRITISH COLUMBIA CANC AGCY,TERRY FOX LAB,601 W 10TH AVE VANCOUVER BC V5Z 1L3 CANADA BRITISH COLUMBIA CANC AGCY,TERRY FOX LAB VANCOUVER BC V5Z 1L3 CANADA UNIV BRITISH COLUMBIA,DEPT EXPT PATHOL & LAB MED VANCOUVER BC V5Z 1M9CANADA UNIV VICTOR SEGALEN,LAB GREFFE DE MOELLE,CNRS,UMR 5540 BORDEAUX FRANCE UNIV BRITISH COLUMBIA,DEPT MED VANCOUVER BC CANADA UNIV BRITISH COLUMBIA,DEPT MED GENET VANCOUVER BC CANADA
Titolo Testata:
Oncogene
fascicolo: 2, volume: 16, anno: 1998,
pagine: 237 - 248
SICI:
0950-9232(1998)16:2<237:BACA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MYELOGENOUS LEUKEMIA; CHRONIC MYELOID-LEUKEMIA; TUMOR-NECROSIS-FACTOR; COLONY-STIMULATING FACTOR; HUMAN HEMATOPOIETIC-CELLS; ACTIVATED PHOSPHATIDYLINOSITOL 3-KINASE; TYROSINE KINASE-ACTIVITY; RAS SIGNALING PATHWAY; LONG-TERM CULTURE; HUMAN BONE-MARROW;
Keywords:
CML; BCR-ABL; CERAMIDE; APOPTOSIS; TYROSINE PHOSPHORYLATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
85
Recensione:
Indirizzi per estratti:
Citazione:
V. Maguersatta et al., "BCR-ABL ACCELERATES C2-CERAMIDE-INDUCED APOPTOSIS", Oncogene, 16(2), 1998, pp. 237-248

Abstract

In patients with chronic myeloid leukemia (CML), the neoplastic (BCR-ABL(+)) progenitor cells are characterized by an increased proliferative activity, Whether these cells are also resistant to apoptosis and if so, under what conditions remains controversial, We now show that highly purified populations of very primitive neoplastic progenitor cells obtained directly from CML patients survive and proliferate in vitrofor several weeks in the absence of any added growth factors (except insulin), In contrast, purified primary normal progenitors maintained under the same conditions die rapidly, Nevertheless, both primary CML cells and BCR-ABL(+) BAF3 cells show the same dose-dependent sensitivity to TNF-alpha or ceramide-induced apoptosis as their respective normal counterparts, In fact, time course studies demonstrated an even faster onset of apoptosis in ceramide-treated BCR-ABL(+) BAF3 cells as compared to normal controls, BCR-ABL(+) cells treated with ceramide alsoshowed a rapid and sequential increase in the tyrosine phosphorylation of p210(BCR-ABL), p46-56(SHC) and p120(Cbl), These findings suggest growth factor deprivation and treatment with TNF-alpha or ceramide trigger different initial events both of which can lead to apoptosis in factor-dependent hematopoietic cells, However, in the first case, activation of apoptosis is blocked by the basal activity of p210(BCR-ABL), whereas in the second, the presence of p210(BCR-ABL) appears to accelerate the onset of apoptosis by a mechanism that may involve an activation of its kinase function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:35:47