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Titolo:
NONINVASIVE DETERMINATION OF LANGUAGE LATERALIZATION BY FUNCTIONAL TRANSCRANIAL DOPPLER SONOGRAPHY - A COMPARISON WITH THE WADA TEST
Autore:
KNECHT S; DEPPE M; EBNER A; HENNINGSEN H; HUBER T; JOKEIT H; RINGELSTEIN EB;
Indirizzi:
UNIV MUNSTER,DEPT NEUROL,ALBERT SCHWEITZER STR 33 D-48129 MUNSTER GERMANY EPILEPSY CTR BETHEL MUNSTER GERMANY
Titolo Testata:
Stroke
fascicolo: 1, volume: 29, anno: 1998,
pagine: 82 - 86
SICI:
0039-2499(1998)29:1<82:NDOLLB>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
WORD GENERATION; FLOW VELOCITY; HEART-RATE; LOCALIZATION; STIMULATION; HANDEDNESS; ACTIVATION; TASKS; MRI;
Keywords:
CEREBRAL DOMINANCE; LATERALITY; ULTRASONOGRAPHY, DOPPLER; WADA TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
S. Knecht et al., "NONINVASIVE DETERMINATION OF LANGUAGE LATERALIZATION BY FUNCTIONAL TRANSCRANIAL DOPPLER SONOGRAPHY - A COMPARISON WITH THE WADA TEST", Stroke, 29(1), 1998, pp. 82-86

Abstract

Background aad Purpose-Functional transcranial Doppler ultrasonography (fTCD) can assess event-related changes in cerebral blood flow velocities and, by comparison between sides, call provide a measure of hemispheric perfusional lateralization, It is easily applicable, insensitive to movement artifacts, and can be used in patients with less than perfect cooperation. In the present study we investigated the validity of fTCD in determining the hemispheric dominance for language by direct comparison of fTCD with intracarotid amobarbital anesthesia (Wada test), Methods-fTCD and the Wada test were performed in 19 patients evaluated for epilepsy surgery. By the Wada test, 13 patients were classified as left-hemisphere dominant and 6 as right-hemisphere dominant forlanguage. fTCD was based on the continuous bilateral measurements of blood now velocities in the middle cerebral arteries and event-relatedaveraging during a cued word generation task previously shown to activate lateralized language areas in normal adults, Results-In 4 patients fTCD assessment was not possible because of lack oi an acoustic temporal bone window. in the remaining 15 candidates, determination of language dominance was concordant with the Wada test in every case, Moreover, the correlation of the lateralization measures h-om both procedures was highly significant (r=.92, P<.0001). Conclusions-This strong correlation validates fTCD as a noninvasive and practical tool for the determination of language lateralization that can be applied for clinical and investigative purposes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 02:50:29