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Titolo:
PROTECTION AGAINST POSTISCHEMIC NEURONAL LOSS IN GERBIL HIPPOCAMPAL CA1 BY GLYCINE(B) AND AMPA ANTAGONISTS
Autore:
LAZAREWICZ JW; GADAMSKI R; PARSONS CG; DANYSZ W;
Indirizzi:
POLISH ACAD SCI,MED RES CTR,PAWINSKIEGO 5 PL-02106 WARSAW POLAND MERZ & CO,DEPT PHARMACOL FRANKFURT GERMANY
Titolo Testata:
Journal of neural transmission
fascicolo: 11-12, volume: 104, anno: 1997,
pagine: 1249 - 1254
SICI:
0300-9564(1997)104:11-12<1249:PAPNLI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSIENT GLOBAL-ISCHEMIA; FOREBRAIN ISCHEMIA; BRAIN; MK-801; DAMAGE; RAT; GLUTAMATE; INJURY;
Keywords:
FOREBRAIN ISCHEMIA; GERBIL; GLYCINE; ANTAGONISTS; MRZ 2/570; MRZ 2/576; NBQX; HIPPOCAMPUS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
J.W. Lazarewicz et al., "PROTECTION AGAINST POSTISCHEMIC NEURONAL LOSS IN GERBIL HIPPOCAMPAL CA1 BY GLYCINE(B) AND AMPA ANTAGONISTS", Journal of neural transmission, 104(11-12), 1997, pp. 1249-1254

Abstract

Novel antagonists of the glycine, site of the NMDA receptor (MRZ 2/570, MRZ 2/576), and an AMPA receptor antagonist, NBQX were tested in 3-min. global ischaemia in gerbils. Untreated animals showed after 14 days a loss of almost 90% of pyramidal neurones in the CA1 region, whichwas prevented by NBQX, and reduced to 50% by both glycine, antagonists. NBQX produced a delayed, long lasting (up to 24 hr) hypothermia while hypothermia with both glycine(B) antagonists was transient.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 09:18:40