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Titolo:
TIME TO PREGNANCY AMONG THE WIVES OF MEN EXPOSED TO ORGANIC-SOLVENTS
Autore:
SALLMEN M; LINDBOHM ML; ANTTILA A; KYYRONEN P; TASKINEN H; NYKYRI E; HEMMINKI K;
Indirizzi:
FINNISH INST OCCUPAT HLTH,DEPT EPIDEMIOL & BIOSTAT,TOPELIUKSENKATU 41A A FIN-00250 HELSINKI FINLAND FINNISH INST OCCUPAT HLTH,DEPT OCCUPAT MED HELSINKI FINLAND
Titolo Testata:
Occupational and environmental medicine
fascicolo: 1, volume: 55, anno: 1998,
pagine: 24 - 30
SICI:
1351-0711(1998)55:1<24:TTPATW>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DRY-CLEANING WORKERS; PERCHLOROETHYLENE EXPOSURE; REPRODUCTIVE OUTCOMES; SPONTANEOUS-ABORTIONS;
Keywords:
FECUNDABILITY; PATERNAL EXPOSURE; SOLVENTS; REPRODUCTIVE HAZARDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
M. Sallmen et al., "TIME TO PREGNANCY AMONG THE WIVES OF MEN EXPOSED TO ORGANIC-SOLVENTS", Occupational and environmental medicine, 55(1), 1998, pp. 24-30

Abstract

Objectives-To assess whether paternal exposure to organic solvents isassociated with decreased fertility. Methods-A retrospective time to pregnancy study was conducted among men biologically monitored for organic solvents. The workers were classified into exposure categories onthe basis of work description and the use of solvents as reported in the questionnaires, and on biological exposure measurements. The relative fecundability density ratios (FDR-an analogue of incidence densityratio of clinically recognised pregnancies) were calculated with discrete proportional hazards regression, Results-After three mailings 316(72.1%) wives of the monitored men participated, The final study population consisted of 282 couples who did not use contraception at the beginning of pregnancy. The FDRs, adjusted for potential confounders, were 0.80 (95% confidence interval (95% CI) 0.57 to 1.11) and 0.74 (95%CI 0.51 to 1.06) for high or frequent and low or intermediate exposure, respectively. High or frequent and low or intermediate exposure were related to decreased fecundability among primigravida (FDRs 0.36; 95% CI 0.19 to 0.66 and 0.53; 95% CI 0.27 to 1.04) but not among coupleswith at least one previous pregnancy (FDRs 0.96; 95% CI 0.62 to 1.49 and 0.77; 95% CI 0.47 to 1.24). Conclusions-The findings of the study provide limited support for the hypothesis that paternal exposure to organic solvents might be associated with decreased fertility. Further studies with careful design are warranted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 23:21:23