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Titolo:
EFFECTS OF NITRIC-OXIDE ON BLOOD-FLOW AND MUCOCILIARY ACTIVITY IN THEHUMAN NOSE
Autore:
RUNER T; LINDBERG S;
Indirizzi:
UNIV LUND HOSP,DEPT OTORHINOLARYNGOL HEAD & NECK SURG S-22185 LUND SWEDEN
Titolo Testata:
The Annals of otology, rhinology & laryngology
fascicolo: 1, volume: 107, anno: 1998,
pagine: 40 - 46
SICI:
0003-4894(1998)107:1<40:EONOBA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RABBIT MAXILLARY SINUS; ARTERIAL SMOOTH-MUSCLE; ENDOTHELIAL-CELLS; OBLIGATORY ROLE; RELAXING FACTOR; NASAL-MUCOSA; SUBSTANCE-P; METHACHOLINE; RELAXATION; RELEASE;
Keywords:
BLOOD FLOW; HUMAN; MUCOCILIARY FUNCTION; NASAL MUCOSA; NITRIC OXIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
T. Runer e S. Lindberg, "EFFECTS OF NITRIC-OXIDE ON BLOOD-FLOW AND MUCOCILIARY ACTIVITY IN THEHUMAN NOSE", The Annals of otology, rhinology & laryngology, 107(1), 1998, pp. 40-46

Abstract

In an animal model, nitric oxide (NO) has been shown to increase mucociliary activity in vivo and ciliary beat frequency in vitro. The aim of the present study was to investigate the effects of NO on blood flow and mucociliary activity in the human nose. The concentration of NO in nasal air was measured with a chemiluminescence technique after nebulizing the NO donor sodium nitroprusside (SNP) at a dose of 3.0 mg into the nose in six volunteers, and was found to increase by 50.1% +/- 10.0% (mean +/- SEM; p <.001) after the SNP challenge. Blood flow measured by laser Doppler flowmetry increased by 67.3% +/- 15.5% (p <.05) after challenge with SNP at 1.0 mg, and by 75.4% +/- 18.5% at 3.0 mg (p <.01; n = 6). The higher dose, which produced no subjective side effects, was then used in the mucociliary experiments. The maximum increase in nasal mucociliary activity was 57.2% +/- 6.7% at 3.0 mg of SNP (n = 5). The findings support the view that NO regulates mucociliary activity and blood flow in the human nasal mucosa.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:14:56