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Titolo:
MOLECULAR BIOLOGICAL INVESTIGATIONS INTO THE ROLE OF THE NMDA RECEPTOR IN THE PATHOPHYSIOLOGY OF SCHIZOPHRENIA
Autore:
CATTS SV; WARD PB; LLOYD A; HUANG XF; DIXON G; CHAHL L; HARPER C; WAKEFIELD D;
Indirizzi:
PRINCE WALES HOSP,PSYCHIAT UNIT,HIGH ST RANDWICK NSW 2031 AUSTRALIA UNIV NEW S WALES,SCH PSYCHIAT SYDNEY NSW AUSTRALIA UNIV NEW S WALES,SCH PATHOL SYDNEY NSW AUSTRALIA UNIV WOLLONGONG,DEPT BIOL SCI WOLLONGONG NSW 2500 AUSTRALIA UNIV NEWCASTLE,NEUROPHARMACOL LAB NEWCASTLE NSW 2308 AUSTRALIA UNIV SYDNEY,DEPT PATHOL SYDNEY NSW 2006 AUSTRALIA
Titolo Testata:
Australian and New Zealand Journal of Psychiatry
fascicolo: 1, volume: 31, anno: 1997,
pagine: 17 - 26
SICI:
0004-8674(1997)31:1<17:MBIITR>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL PYRAMIDAL CELL; MEDIAL TEMPORAL-LOBE; GRAY-MATTER VOLUME; MAGNETIC-RESONANCE; SYNAPTIC DENSITY; CEREBRAL-CORTEX; STRUCTURAL ABNORMALITIES; AFFECTIVE-DISORDER; PREFRONTAL CORTEX; BRAIN MORPHOLOGY;
Keywords:
NEURODEVELOPMENT; NMDA RECEPTOR; SCHIZOPHRENIA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
110
Recensione:
Indirizzi per estratti:
Citazione:
S.V. Catts et al., "MOLECULAR BIOLOGICAL INVESTIGATIONS INTO THE ROLE OF THE NMDA RECEPTOR IN THE PATHOPHYSIOLOGY OF SCHIZOPHRENIA", Australian and New Zealand Journal of Psychiatry, 31(1), 1997, pp. 17-26

Abstract

Objective: There is increasing acceptance that schizophrenia is associated with a generalised disorder in cortical neurodevelopment. The aim of this paper is to review the evidence that this disorder may be accounted for by abnormalities in mechanisms mediated by the main familyof excitatory neuroreceptors in cortical brain systems, the N-methyl-D-aspartate (NMDA) glutamatergic receptors. Method: The neurobiological evidence is presented for an abnormality in cortical development related to synaptic pathology in schizophrenia. The unique functions of the NMDA receptor in information processing are described, especially its role in learning and memory, and in neural plasticity and brain development. It is argued that the cellular and molecular mechanisms which underlie learning and memory also govern normal brain development, Studies examining abnormalities in glutamatergic transmission in schizophrenia are reviewed. Results: There is a substantial literature in support of the possibility that NMDA receptor abnormalities may be involved in the neurodevelopmental predisposition to schizophrenia, as wellas in symptom production. Conclusions: Research to determine the roleof the NMDA receptor in the pathophysiology of schizophrenia is warranted and now feasible, To be successful, this research will require the application of molecular biology techniques to postmortem brain tissue studies, in addition to traditional histochemical approaches.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:05:51