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Titolo:
EXPRESSION OF ARTHRITIS-CAUSING HLA-B27 ON HELA-CELLS PROMOTES INDUCTION OF C-FOS IN RESPONSE TO IN-VITRO INVASION BY SALMONELLA-TYPHIMURIUM
Autore:
IKAWA T; IKEDA M; YAMAGUCHI A; TSAI WC; TAMURA N; SETA N; TRUCKSESS M; RAYBOURNE RB; YU DTY;
Indirizzi:
UNIV CALIF LOS ANGELES,DIV RHEUMATOL,REHABIL CTR 35 40,SCH MED,1000 VET AVE LOS ANGELES CA 90095 UNIV CALIF LOS ANGELES,DIV RHEUMATOL,REHABIL CTR 35 40,SCH MED LOS ANGELES CA 90095 US FDA,CTR FOOD SAFETY & APPL NUTR WASHINGTON DC 20204 US FDA,IMMUNOBIOL BRANCH LAUREL MD 20708
Titolo Testata:
The Journal of clinical investigation
fascicolo: 1, volume: 101, anno: 1998,
pagine: 263 - 272
SICI:
0021-9738(1998)101:1<263:EOAHOH>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; MHC CLASS-I; ANKYLOSING-SPONDYLITIS; EPITHELIAL-CELLS; REACTIVE ARTHRITIS; BACTERIAL INVASION; T-CELLS; PHOSPHORYLATION; CYTOKINES; MOLECULES;
Keywords:
HLA-B27; REACTIVE ARTHRITIS; C-FOS; AP-1; MCP-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
T. Ikawa et al., "EXPRESSION OF ARTHRITIS-CAUSING HLA-B27 ON HELA-CELLS PROMOTES INDUCTION OF C-FOS IN RESPONSE TO IN-VITRO INVASION BY SALMONELLA-TYPHIMURIUM", The Journal of clinical investigation, 101(1), 1998, pp. 263-272

Abstract

HLA-B27 confers a very strong genetic predisposition to development of a reactive arthritis after infection by bacteria such as Salmonella typhimurium, This study examines the role of HLA-B27 in the initiationof the earliest host activities after exposure to Salmonella, namely activation of the immediate early genes in the epithelial cells, Our major finding is that in Hela cells, the expression of c-fos was induced by Salmonella invasion only when the cells expressed the transfectedHLA-B27 gene, but not the HLA-A1 gene or a truncated HLA-B27 gene lacking the exons encoding the cytoplasmic domain, C-fos is potentially capable of complexing with members of the c-jun family to become the AP-1 transcription complex. Parallel to c-fos expression, we found that only with the HLA-B27 transfectant was there expression of AP-1, AP-1 potentially controls the expression of a large number of genes, On screening a panel of proinflammatory molecules, we found that Salmonella invasion induced expression of monocyte chemoattractant protein-1 in the HLA-B27 cells, Since each of these separate positive findings belong to the same cascade of events after cell activation, together they reinforce the hypothesis that HLA-B27 plays a modulatory role in the early signal transduction events induced by Salmonella invasion, This hypothesis adds another item to the list of allele-specific activities carried out by HLA class I molecules. If similar activation also occursin the joints, it may play a major role in arthritis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:06:57