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Titolo:
MESODERM INDUCTION BY HETERODIMERIC AP-1 (C-JUN AND C-FOS) AND ITS INVOLVEMENT IN MESODERM FORMATION THROUGH THE EMBRYONIC FIBROBLAST GROWTH-FACTOR XBRA AUTOCATALYTIC LOOP DURING THE EARLY DEVELOPMENT OF XENOPUS EMBRYOS
Autore:
KIM J; LIN JJ; XU RH; KUNG HF;
Indirizzi:
NCI,LAB BIOCHEM PHYSIOL,DIV BASIC SCI,FREDERICK CANC RES & DEV CTR,NIH FREDERICK MD 21702 NCI,LAB BIOCHEM PHYSIOL,DIV BASIC SCI,FREDERICK CANC RES & DEV CTR,NIH FREDERICK MD 21702 SCI APPLICAT INT CORP,INTRAMURAL RES & SUPPORT PROGRAM FREDERICK MD 21702
Titolo Testata:
The Journal of biological chemistry
fascicolo: 3, volume: 273, anno: 1998,
pagine: 1542 - 1550
SICI:
0021-9258(1998)273:3<1542:MIBHA(>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAP KINASE; NULL MUTATION; REQUIRES FGF; EXPRESSION; ACTIVIN; ACTIVATION; DORSAL; SPECIFICATION; GASTRULATION; SIGNALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
J. Kim et al., "MESODERM INDUCTION BY HETERODIMERIC AP-1 (C-JUN AND C-FOS) AND ITS INVOLVEMENT IN MESODERM FORMATION THROUGH THE EMBRYONIC FIBROBLAST GROWTH-FACTOR XBRA AUTOCATALYTIC LOOP DURING THE EARLY DEVELOPMENT OF XENOPUS EMBRYOS", The Journal of biological chemistry, 273(3), 1998, pp. 1542-1550

Abstract

We have previously demonstrated the involvement of AP-1/Jun in fibroblast growth factor (FGF) signaling by loss-of-function assay (Dong, Z., Xu, R.-H., Kim, J., Zhan, S.-N., Ma, W.-Y., Colburn, N. H., and Kung, H. (1996) J. Biol, Chem. 271, 9942-9946), Further investigations by gain-of-function are reported in this study, AP-1 transactivation activity was increased by the treatment of animal cap explants with FGF, Ectopic overexpression of two components of AP-1 (c-jun and c-fos together, but not alone) produced posteriorized embryos and induced mesoderm formation in animal cap explants, indicating that both AP-1 heterodimers are required for mesoderm induction, Since Ras/AP-1 functions downstream of FGF signaling, we then tested the involvement of Ras/AP-1 in mesoderm maintenance mediated by embryonic FGF/ Xbra using dominant-negative mutants, Mesoderm maintenance mediated by embryonic FGF/Xbra was blocked by dominant-negative mutants of Ras/AP-1, and AP-1 enhanced the expression of Xbra, Further studies demonstrated the inhibition of Ras/AP-1-mediated mesoderm formation by dominant-negative mutants of the FGF receptor and Xbra, These results indicate that Ras/ AP-1 andFGF/Xbra signals are involved in the mesoderm maintenance machinery and mesoderm formation through the synergistic action of the diversified signal pathways derived from the FGF/Xbra autocatalytic loop.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:22:45