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Titolo:
INVOLVEMENT OF THE PELVIC PLEXUS AND THE SUPRARENAL GANGLIA IN THE NEUROPEPTIDE-Y (NPY) INNERVATION OF THE CERVIX AND THE UTERUS OF THE RAT
Autore:
SERGHINI R; PRUDHOMME MJ; VAUDRY H; ROUSSEAU JP;
Indirizzi:
UNIV PARIS 06,REPROD PHYSIOL LAB,INRA,URA CNRS 1449,4 PL JUSSIEU F-75252 PARIS 05 FRANCE UNIV ROUEN,INST FEDERAT RECH MULTIDISCIPLINAIRES PEPTIDES,LAB NEUROENDOCRINOL CELLULAIRE & MOL F-76821 MONT ST AIGNAN FRANCE
Titolo Testata:
Journal of the autonomic nervous system
fascicolo: 1-2, volume: 67, anno: 1997,
pagine: 38 - 50
SICI:
0165-1838(1997)67:1-2<38:IOTPPA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GUINEA-PIG; NERVE-FIBERS; FEMALE RAT; UTERINE CERVIX; SMOOTH-MUSCLE; (NPY)-LIKE IMMUNOREACTIVITY; EXTRINSIC INNERVATION; NORADRENERGIC NERVES; REPRODUCTIVE-TRACT; CO-EXISTENCE;
Keywords:
FEMALE GENITAL TRACT; NEUROPEPTIDE Y; PELVIC PLEXUS; SUPRARENAL GANGLIA; RAT;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
R. Serghini et al., "INVOLVEMENT OF THE PELVIC PLEXUS AND THE SUPRARENAL GANGLIA IN THE NEUROPEPTIDE-Y (NPY) INNERVATION OF THE CERVIX AND THE UTERUS OF THE RAT", Journal of the autonomic nervous system, 67(1-2), 1997, pp. 38-50

Abstract

The involvement of the pelvic plexus and suprarenal ganglia in the neuropeptide Y (NPY) innervation of the genital tract was studied in thefemale rat by means of denervation experiments and retrograde tracingstudies. Removal of the paracervical ganglia caused a significant decrease of the NPY-immunoreactive nerve density and NPY concentration inthe lower part of the genital tract: cervix, uterine body and lower part of the uterine horn. The decrease in NPY concentration in these three regions was more pronounced after lesion of the pelvic plexus, Lesion of the ovarian nerve plexus caused a depletion in the NPY-immunoreactive nerve fibres and a decrease in NPY concentration in the upper part of the uterine horn. Pelvic nerve section, inferior mesenteric ganglia excision and superior ovarian nerve section had no effect on the NPY innervation in the genital tract, Injection of fluorogold inter the cervix and lower part of the uterus combined with immunohistochemistry revealed that 87.5% of labelled neurons in the pelvic plexus were NPY-immunoreactive. Following injection of fluorogold into the upper part of the uterus, 92% of labelled neurons in the suprarenal ganglia were NPY-immunoreactive, Treatment with 6-hydroxydopamine revealed that the NPY-immunoreactive nerve fibres were non-noradrenergic in the cervix, but were noradrenergic in the upper part of the uterus. In the uterine body and lower part of the uterine horn, both noradrenergic and non-noradrenergic NPY-immunoreactive nerve fibres were observed. These data demonstrate the major contribution of pelvic plexus neurons in the non-noradrenergic NPY innervation of the lower part of the genital tract, and the Involvement of the suprarenal ganglia in the noradrenergic NPY innervation of the upper part of the uterus via the ovarian nerve plexus. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:37:41