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Titolo:
AMPA RECEPTORS ARE COUPLED TO THE NITRIC-OXIDE CYCLIC-GMP PATHWAY IN CEREBELLAR ASTROGLIAL CELLS
Autore:
BALTRONS MA; GARCIA A;
Indirizzi:
UNIV AUTONOMA BARCELONA,INST BIOL FUNDAMENTAL V VILLAR PALASI BELLATERRA 08193 SPAIN UNIV AUTONOMA BARCELONA,INST BIOL FUNDAMENTAL V VILLAR PALASI BELLATERRA 08193 SPAIN UNIV AUTONOMA BARCELONA,DEPT BIOQUIM & BIOL MOL BELLATERRA 08193 SPAIN
Titolo Testata:
European journal of neuroscience
fascicolo: 11, volume: 9, anno: 1997,
pagine: 2497 - 2501
SICI:
0953-816X(1997)9:11<2497:ARACTT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLIAL-CELLS; KAINATE RECEPTORS; GLUTAMATE RECEPTORS; NADPH DIAPHORASE; PRIMARY CULTURES; RAT CEREBELLUM; CONCANAVALIN-A; GRANULE CELLS; SYNTHASE; ASTROCYTES;
Keywords:
CYCLOTHIAZIDE; CO2+ UPTAKE; GLUTAMATE; KAINATE; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
M.A. Baltrons e A. Garcia, "AMPA RECEPTORS ARE COUPLED TO THE NITRIC-OXIDE CYCLIC-GMP PATHWAY IN CEREBELLAR ASTROGLIAL CELLS", European journal of neuroscience, 9(11), 1997, pp. 2497-2501

Abstract

In cultured rat cerebellar astroglia kainate induces cGMP formation with low potency (EC50 310 mu M). In the presence of cyclothiazide, a blocker of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)receptor desensitization, the effect of kainate was potentiated and glutamate and AMPA elicited large increases (>100-fold) in cGMP levels. The response to all three agonists was abolished by the nitric oxide synthase inhibitor N-G-nitro-L-arginine and required extracellular calcium. Uptake of Co2+ was induced by AMPA in a limited population of astroglial cells and this effect was potentiated by cyclothiazide. Theseresults indicate that calcium-permeable AMPA receptors mediate stimulation of nitric oxide formation in cerebellar astroglia. This effect may be relevant for glutamate-dependent synaptic plasticity processes in the cerebellum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 10:49:07