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Titolo:
SPATIAL-LEARNING DEFICITS IN MICE WITH A TARGETED GLUCOCORTICOID RECEPTOR GENE DISRUPTION
Autore:
OITZL MS; DEKLOET ER; JOELS M; SCHMID W; COLE TJ;
Indirizzi:
LEIDEN UNIV,LEIDEN AMSTERDAM CTR DRUG RES,DIV MED PHARMACOL,POB 9503 NL-2300 RA LEIDEN NETHERLANDS UNIV AMSTERDAM,DEPT EXPT ZOOL NL-1098 SM AMSTERDAM NETHERLANDS GERMAN CANC RES CTR,DIV MOL BIOL CELL 1 D-6900 HEIDELBERG GERMANY
Titolo Testata:
European journal of neuroscience
fascicolo: 11, volume: 9, anno: 1997,
pagine: 2284 - 2296
SICI:
0953-816X(1997)9:11<2284:SDIMWA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
II CORTICOSTEROID RECEPTORS; LONG-TERM POTENTIATION; DAY-OLD CHICKS; ELECTROCONVULSIVE SHOCK; SELECTIVE IMPAIRMENT; SYNAPTIC PLASTICITY; HIPPOCAMPAL-LESIONS; MEMORY IMPAIRMENT; WATER MAZE; RAT-BRAIN;
Keywords:
BEHAVIORAL REACTIVITY; IMPAIRMENT OF HIPPOCAMPAL FUNCTION; MINERALOCORTICOID RECEPTOR; WATER MAZE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Oitzl et al., "SPATIAL-LEARNING DEFICITS IN MICE WITH A TARGETED GLUCOCORTICOID RECEPTOR GENE DISRUPTION", European journal of neuroscience, 9(11), 1997, pp. 2284-2296

Abstract

Previous studies in rats using the Morris water maze suggested that the processing of spatial information is modulated by corticosteroid hormones through mineralocorticoid and glucocorticoid receptors in the hippocampus. Mineralocorticoid receptors appear to be involved in the modulation of explorative behaviour, while additional activation of glucocorticoid receptors facilitates the storage of information. In the present study we used the water maze task to examine spatial learning and memory in mice homozygous and heterozygous for a targeted disruption of the glucocorticoid receptor gene. Compared with wild-type controls, homozygous and heterozygous mice were impaired in the processing ofspatial but not visual information. Homozygous mutants performed variably during training, without specific platform-directed search strategies. The spatial learning disability was partly compensated for by increased motor activity. The deficits were indicative of a dysfunction of glucocorticoid receptors as well as of mineralocorticoid receptors. Although the heterozygous mice performed similarly to wild-type mice with respect to latency to find the platform, their strategy was more similar to that of the homozygous mice. Glucocorticoid receptor-related long-term spatial memory was impaired. The increased behavioural reactivity of the heterozygous mice in the open field points to a more prominent mineralocorticoid receptor-mediated function. The findings indicate that (i) the glucocorticoid receptor is of critical importance for the control of spatial behavioural functions, and (ii) mineralocorticoid receptor-mediated effects on this behaviour require interaction with functional glucocorticoid receptors. Until the development of site-specific, inducible glucocorticoid receptor mutants, glucocorticoid receptor-knockout mice present the only animal model for the study of corticosteroid-mediated effects in the complete absence of a functional receptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:36:32