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Titolo:
SEROTONIN FUNCTION IN HUMAN-SUBJECTS - INTERCORRELATIONS AMONG CENTRAL 5-HT INDEXES AND AGGRESSIVENESS
Autore:
COCCARO EF; KAVOUSSI RJ; TRESTMAN RL; GABRIEL SM; COOPER TB; SIEVER LJ;
Indirizzi:
MED COLL PENN & HAHNEMANN UNIV,SCH MED,DEPT PSYCHIAT,3200 HENRY AVE PHILADELPHIA PA 19129 CUNY MT SINAI SCH MED,DEPT PSYCHIAT NEW YORK NY 10029 NATHAN S KLINE INST PSYCHIAT RES,ANALYT PSYCHOPHARMACOL LAB ORANGEBURG NY 10962
Titolo Testata:
Psychiatry research
fascicolo: 1-2, volume: 73, anno: 1997,
pagine: 1 - 14
SICI:
0165-1781(1997)73:1-2<1:SFIH-I>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLUID MONOAMINE METABOLITES; HEALTHY-HUMAN SUBJECTS; DEFICIT HYPERACTIVITY DISORDER; DISRUPTIVE BEHAVIOR DISORDERS; D-FENFLURAMINE CHALLENGE; CEREBROSPINAL-FLUID; PROLACTIN RESPONSE; META-CHLOROPHENYLPIPERAZINE; PERSONALITY-DISORDERS; SUICIDE VICTIMS;
Keywords:
SEROTONIN; AGGRESSION; CEREBROSPINAL FLUID 5-HIAA; FENFLURAMINE; M-CPP;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
E.F. Coccaro et al., "SEROTONIN FUNCTION IN HUMAN-SUBJECTS - INTERCORRELATIONS AMONG CENTRAL 5-HT INDEXES AND AGGRESSIVENESS", Psychiatry research, 73(1-2), 1997, pp. 1-14

Abstract

Three central indices of serotonin (5-HT) system activity in human subjects were examined to: (a) estimate intercorrelations among 5-HT indices and (b) compare correlations of these indices with a measure of assaultiveness (Buss-Durkee 'Assault') in personality-disordered individuals. Cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) concentration and prolactin responses to m-chlorophenylpiperazine (m-CPP) m-CPP (PRL[m-CPP]) and fenfluramine (PRL[FEN]), served as indices of pre-, post- and 'net'-synaptic central 5-HT activity, respectively. PRL[D,L-FEN] responses were inversely related to CSF 5-HIAA concentration and positively correlated with PRL[m-CPP] responses. Both PRL[D,L-FEN] and PRL[m-CPP] response data correlated equally, and inversely, with ED Buss-Durkee Assault when the same subjects were examined. BasalCSF 5-HIAA concentration did not correlate with Buss-Durkee 'Assault'. PRL responses to challenge probes which involve activation of 5-HT post-synaptic receptors may correlate better than a basal measure of pre-synaptic 5-HT function with a tendency to assaultive behavior in non-criminally aggressive personality-disordered individuals. (C) 1997 Elsevier Science Ireland Ltd.

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Documento generato il 17/01/20 alle ore 20:48:51