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Titolo:
CONTRAST DETECTION, DISCRIMINATION AND ADAPTATION IN PATIENTS WITH PARKINSONS-DISEASE AND MULTIPLE SYSTEM ATROPHY
Autore:
VANELST LT; GREENLEE MW; FOLEY JM; LUCKING CH;
Indirizzi:
UNIV FREIBURG,NEUROL KLIN D-79106 FREIBURG GERMANY UNIV FREIBURG,NEUROL KLIN D-79106 FREIBURG GERMANY UNIV CALIF SANTA BARBARA,DEPT PSYCHOL SANTA BARBARA CA 93106
Titolo Testata:
Brain
, volume: 120, anno: 1997,
parte:, 12
pagine: 2219 - 2228
SICI:
0006-8950(1997)120:<2219:CDDAAI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRIATE CORTICAL-NEURONS; VISUAL-EVOKED-POTENTIALS; SIMPLE REACTION-TIME; SPATIAL CONTRAST; SYNAPTIC ORGANIZATION; DOPAMINE DEFICIENCY; TEMPORAL FREQUENCY; AMACRINE CELLS; HUMAN-VISION; SENSITIVITY;
Keywords:
CONTRAST DISCRIMINATION; ADAPTATION; PARKINSONS DISEASE; MULTIPLE SYSTEM ATROPHY; NEURODEGENERATIVE DISEASES;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
76
Recensione:
Indirizzi per estratti:
Citazione:
L.T. Vanelst et al., "CONTRAST DETECTION, DISCRIMINATION AND ADAPTATION IN PATIENTS WITH PARKINSONS-DISEASE AND MULTIPLE SYSTEM ATROPHY", Brain, 120, 1997, pp. 2219-2228

Abstract

Visual spatial contrast thresholds and suprathreshold contrast matches were measured before and after adaptation to high-contrast sinewave gratings in patients with Parkinson's disease (n = 27), patients with multiple system atrophy (n = 6) and a group of age-matched control patients without CNS disease (n = 27). Contrast thresholds were higher inthe Parkinson's disease patients than in either the multiple system atrophy patients or control patients. The effect of contrast adaptationon both contrast thresholds and matches was approximately equal in the three groups. This suggests that contrast adaptation is not affectedby these CNS disorders and is consistent with the hypothesis that theloss in contrast sensitivity in Parkinson's disease is mediated by retinal effects. The results are discussed in terms of the underlying pathology of the visual deficits in Parkinson's disease and the possiblediagnostic implications for differentiating Parkinson's disease and multiple system atrophy.

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Documento generato il 22/10/20 alle ore 03:08:58