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Titolo:
SILIBININ, A PLANT-EXTRACT WITH ANTIOXIDANT AND MEMBRANE STABILIZING PROPERTIES, PROTECTS EXOCRINE PANCREAS FROM CYCLOSPORINE-A TOXICITY
Autore:
VONSCHONFELD J; WEISBROD B; MULLER MK;
Indirizzi:
MED CLIN,DEPT GASTROENTEROL,HUFELANDSTR 55 D-45122 ESSEN GERMANY MED CLIN GASTROENTEROL 4 D-68135 MANNHEIM GERMANY MARIEN HOSP,MED CLIN D-49047 OSNABRUCK GERMANY
Titolo Testata:
Cellular and molecular life sciences
fascicolo: 11-12, volume: 53, anno: 1997,
pagine: 917 - 920
SICI:
1420-682X(1997)53:11-12<917:SAPWAA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISLET-ACINAR AXIS; LIPID-PEROXIDATION; SILYMARIN; RAT; LIVER;
Keywords:
SILIBININ; CYCLOSPORINE A; ENDOCRINE PANCREAS; EXOCRINE PANCREAS; INSULIN; AMYLASE;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
J. Vonschonfeld et al., "SILIBININ, A PLANT-EXTRACT WITH ANTIOXIDANT AND MEMBRANE STABILIZING PROPERTIES, PROTECTS EXOCRINE PANCREAS FROM CYCLOSPORINE-A TOXICITY", Cellular and molecular life sciences, 53(11-12), 1997, pp. 917-920

Abstract

Silymarin can be extracted from the milk thistle, and silibinin is the main component of the plant extract. Possibly due to their antioxidant and membrane-stabilizing properties, the compounds have been shown to protect different organs and cells against a number of insults. Thus liver, kidney, erythrocytes and platelets have been protected from the toxic effects of ethanol, carbon tetrachloride, cold ischemia and drugs, respectively. The effect of silibinin on endocrine and exocrine pancreas, however, has not been studied. We therefore investigated whether silibinin treatment attenuates cyclosporin A (CiA) toxicity on rat endocrine and exocrine pancreas. Groups of 15 male Wistar rats were treated for 8 days with CiA and/or silibinin. On day 9, endocrine and exocrine pancreatic functions were tested in vitro. At the end of the treatment period, blood glucose levels in vivo were significantly higher in rats treated with CiA, while silibinin did not affect glucose levels. In vitro, insulin secretion was inhibited after treatment with silibinin, but amylase secretion was not affected. After treatment withCiA both insulin and amylase secretion were reduced. Silibinin and CIA had an additive inhibitory effect on insulin secretion, but silibinin attenuated CiA-induced inhibition of amylase secretion. Despite CiA treatment, amylase secretion was in fact restored to normal with the highest dose of silibinin. Thus silibinin inhibits glucose-stimulated insulin release in vitro, while not affecting blood glucose concentration in vivo. This combination of effects could be useful in the treatment of non-insulin-dependent diabetes mellitus. Furthermore, silibinin protects the exocrine pancreas from CiA toxicity. As this inhibitory effect is probably unspecific, silibinin may also protect the exocrine pancreas against other insult principles, such as alcohol.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:33:17