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Titolo:
INDUCTION OF FLAVIN-CONTAINING MONOOXYGENASE (FMO1) BY A POLYCYCLIC AROMATIC HYDROCARBON, 3-METHYLCHOLANTHRENE, IN RAT-LIVER
Autore:
CHUNG WG; PARK CS; ROH HK; CHA YN;
Indirizzi:
INHA UNIV,COLL MED,DEPT PHARMACOL & TOXICOL INCHON 402751 SOUTH KOREA INHA UNIV,COLL MED,DEPT PHARMACOL & TOXICOL INCHON 402751 SOUTH KOREA
Titolo Testata:
Molecules and cells
fascicolo: 6, volume: 7, anno: 1997,
pagine: 738 - 741
SICI:
1016-8478(1997)7:6<738:IOFM(B>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT EXPRESSION; HORMONAL-REGULATION; RABBIT LUNG; CDNA; SPECIFICITY; METABOLISM; MICROSOMES; PREGNANCY; STEROIDS; ENZYMES;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
W.G. Chung et al., "INDUCTION OF FLAVIN-CONTAINING MONOOXYGENASE (FMO1) BY A POLYCYCLIC AROMATIC HYDROCARBON, 3-METHYLCHOLANTHRENE, IN RAT-LIVER", Molecules and cells, 7(6), 1997, pp. 738-741

Abstract

Flavin-containing monooxygenase (FMO), known not to be induced by xenobiotics, has been induced by a polycyclic aromatic hydrocarbon, 3-methylcholanthrene (3MC). We have found a prominent augmentation of hepatic FMO1 both at transcription and translation levels by pretreatment of rats with 3MC. Liver tissues were used to study the inductive effectof 3MC on the FMO1 isoform, the major form present in rat liver. Evidence for significant induction of rat FMO1 was observed in mRNA production (3.5 fold) identified from reverse transcription-polymerase chainreaction (RT-PCR) results. Induction was also seen in the catalytic activity of the enzyme (2.9 fold) as measured by the thiobenzamide S-oxidation assay using induced rat Liver microsomes. Our finding is the first report to indicate that hepatic FMO1 can be induced with a polycyclic aromatic hydrocarbon compound. FMO plays crucial roles in the oxidation of N- and S-containing drugs. If FMO is also inducible with other environmental polyaromatic hydrocarbon compounds in general, this finding will have important consequences in understanding the altered half-lives of many clinically useful drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:35:02