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Titolo:
IS THERE AN ANTIDEPRESSIVE EFFECT OF THE ANTIPSYCHOTIC SUBSTANCE ZOTEPINE - COMPARISON OF TREATMENT OF DELUSIONAL DEPRESSION WITH ZOTEPINE ONLY OR IN COMBINATION WITH AN ANTIDEPRESSANT
Autore:
WOLFERSDORF M; KONIG F; BARG T;
Indirizzi:
NERVENKRANKENHAUS BAYREUTH,KLIN PSYCHIAT & PSYCHOTHERAPIE,NORDRING 2 D-95445 BAYREUTH GERMANY UNIV ULM,ABT DEPRESS,ABT PSYCHIATRIE,ZFP WEISSENAU D-89069 ULM GERMANY
Titolo Testata:
Nervenheilkunde
fascicolo: 10, volume: 16, anno: 1997,
pagine: 571 - 574
SICI:
0722-1541(1997)16:10<571:ITAAEO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
GER
Keywords:
DELUSIONAL DEPRESSION; ZOTEPINE; ANTIDEPRESSANTS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
M. Wolfersdorf et al., "IS THERE AN ANTIDEPRESSIVE EFFECT OF THE ANTIPSYCHOTIC SUBSTANCE ZOTEPINE - COMPARISON OF TREATMENT OF DELUSIONAL DEPRESSION WITH ZOTEPINE ONLY OR IN COMBINATION WITH AN ANTIDEPRESSANT", Nervenheilkunde, 16(10), 1997, pp. 571-574

Abstract

Clinical observations indicate that the antipsychotic substance zotepine is effective as an antipsychotic, sedative-anxiolytic, and possibly even as an thymoleptic drug. This matter was studied by comparing the course of Hamilton Depression Scale (24-Itemversion) in three open observation periods involving depressive inpatients consecutively admitted because of depression with delusional symptoms. Group 1 was treated only with zotepin, group 2 with zotepin plus amitriptyline or maprotiline, group 3 received zotepine plus paroxetine (20 mg daily). All three groups showed a significant (p < 0.01) improvement in the varianceanalysis (no group or interaction effects). So-called delusional items improved significantly (p < 0.01) in all three groups in the course of the study. Using a rank analysis of variance from day 1 to 14, the sum of ''affective items'' shows a significant decrease (p < 0.01), with no groups or interaction effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:14:29