Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
LOW-DOSE INTRAVENOUS BOLUS INTERLEUKIN-2 WITH INTERFERON-ALPHA THERAPY FOR METASTATIC MELANOMA AND RENAL-CELL CARCINOMA
Autore:
KARP SE;
Indirizzi:
VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DIV SURG ONCOL,POB 980011 RICHMOND VA 23298 SIR MORTIMER B DAVIS JEWISH HOSP,DEPT SURG MONTREAL PQ H3T 1E2 CANADA SIR MORTIMER B DAVIS JEWISH HOSP,DEPT ONCOL MONTREAL PQ H3T 1E2 CANADA MCGILL UNIV MONTREAL PQ CANADA
Titolo Testata:
Journal of immunotherapy
fascicolo: 1, volume: 21, anno: 1998,
pagine: 56 - 61
SICI:
1524-9557(1998)21:1<56:LIBIWI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY ANTIGENS; ADVANCED MALIGNANT-MELANOMA; ACTIVATED KILLER CELLS; PHASE-II TRIAL; RECOMBINANT INTERLEUKIN-2; SUBCUTANEOUS INTERLEUKIN-2; ALFA-2A; CANCER; COMBINATION; IMMUNOTHERAPY;
Keywords:
IMMUNOTHERAPY; TOXICITY; MALIGNANT MELANOMA; RENAL CELL CARCINOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
S.E. Karp, "LOW-DOSE INTRAVENOUS BOLUS INTERLEUKIN-2 WITH INTERFERON-ALPHA THERAPY FOR METASTATIC MELANOMA AND RENAL-CELL CARCINOMA", Journal of immunotherapy, 21(1), 1998, pp. 56-61

Abstract

High-dose therapy with interleukin-2 (IL-2) can produce significant responses in patients with metastatic melanoma (MM) and renal cell carcinoma (RCC). Several studies have shown the benefit of low-dose IL-2 in patients with RCC, but few studies have evaluated low-dose IL-2 in MM. We have used the following regimen: Interferon-alpha 10 million units subcutaneously on days 1, 3, 5, 8, 10, 12, 22, 24, and 26; and IL-260,000 IU/kg i.v. every 8 h on days 8-12 and 22-26. Patients had measurable MM or RCC and were excluded for ECOG status >3, brain metastases, or significant cardiopulmonary or renal dysfunction. Between January 1993 and April 1996, 38 patients with MM and 14 with RCC were treated. In MM, there were six responses !(15.7%; 95% confidence interval 4.1-27.3%) (i.e., one complete response and five partial responses). Responses were seen in visceral and nodal disease. Responses were of goodduration: 40+, 26+, 13, 6, 4, and 3 months. One response was seen in the 14 RCC patients. Treatment was considerably less toxic than with high-dose IL-2. All treatment was given in a medical or surgical ward with intensive care necessary in only two patients. Mon than 80% of patients received >80% of the predicted dose of IL-2. Dose-limiting toxicity consisted mainly of mild confusion or fatigue. In summary, this regimen is batter tolerated and produces response rates within the rangereported for high-dose IL-2 for patients with MM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 06:36:21