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Titolo:
ROLE OF INTERLEUKIN-1-BETA IN SUPEROVULATION IN RATS
Autore:
ONO M; NAKAMURA Y; TAMURA H; TAKIGUCHI S; SUGINO N; KATO H;
Indirizzi:
YAMAGUCHI UNIV,SCH MED,DEPT OBSTET & GYNECOL,1144 KOGUSHI UBE YAMAGUCHI 755 JAPAN YAMAGUCHI UNIV,SCH MED,DEPT OBSTET & GYNECOL UBE YAMAGUCHI 755 JAPAN
Titolo Testata:
Endocrine journal
fascicolo: 6, volume: 44, anno: 1997,
pagine: 797 - 804
SICI:
0918-8959(1997)44:6<797:ROIISI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
GONADOTROPIN-INDUCED OVULATION; PLASMINOGEN-ACTIVATOR; OVARIAN-CELLS; PREOVULATORY FOLLICLES; PERIOVULATORY PERIOD; RECEPTOR ANTAGONIST; MEDIATED REGULATION; TISSUE-TYPE; ADULT-RATS; EXPRESSION;
Keywords:
INTERLEUKIN-1-BETA; SUPEROVULATION; FOLLICLE; PMSG; IMMATURE RAT;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
M. Ono et al., "ROLE OF INTERLEUKIN-1-BETA IN SUPEROVULATION IN RATS", Endocrine journal, 44(6), 1997, pp. 797-804

Abstract

In this study, the changes in interleukin-1 beta (IL-1 beta) mRNA expression and its localization in the ovary were studied in pregnant mares' serum gonadotropin (PMSG)-human CG (hCG) injected immature rats. Moreover, to study the in vivo role of IL-1 during ovulation, the IL-1 receptor antagonist (IL-1ra) was injected into the bilateral bursae (100 mu g/15 mu l/bursa) immediately or at the 3rd, 5th, 10th h after hCG injection. IL-1 beta mRNA expression in the ovary had significantly (P<0.05) increased at the 6th h after hCG injection, and its level depended on the time interval between PMSG and hCG injections; the maximal IL-1 beta mRNA expression was observed when hCG was injected 48 h after the PMSG injection. The signals of IL-1 beta mRNA localized in thethecal layer, particularly in the large preovulatory follicles. Intrabursal IL-1ra injection at the 3rd h after hCG injection showed a trend toward lowering the number of ova shed, and the injection at the th h significantly (P<0.01) decreased the number of ova shed compared with the saline injected control group. At the 24th h after hCG injection, there were a few large preovulatory follicles with distinguishable theca and granulosa layers in the IL-1ra treated ovary, although these two layers were indistinguishable in the control ovary. These results indicated that IL-1 beta mRNA expression was definitely induced by hCGstimulation, and, moreover, this expression was dependent on the stage of follicular maturation. IL-1 may be important for the ovulation inthe superovulatory cycle by PMSG in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 05:00:06