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Titolo:
STUDY OF POSTVACCINAL SECRETORY IMMUNITY TO INFLUENZA-A AND INFLUENZA-B VIRUSES BY ENZYME-IMMUNOASSAY WITH A NEW MONOCLONAL EIA KIT
Autore:
NAIKHIN AN; DONINA SA; KUSTIKOVA YG; KATORGINA LG; KIM TN; RUDENKO LG;
Indirizzi:
RUSSIAN ACAD MED SCI,EXPT MED RES INST ST PETERSBURG RUSSIA
Titolo Testata:
Voprosy virusologii
fascicolo: 6, volume: 42, anno: 1997,
pagine: 271 - 275
SICI:
0507-4088(1997)42:6<271:SOPSIT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
RUS
Soggetto:
CHRONICALLY ILL ADULTS; VACCINES; IMMUNIZATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
A.N. Naikhin et al., "STUDY OF POSTVACCINAL SECRETORY IMMUNITY TO INFLUENZA-A AND INFLUENZA-B VIRUSES BY ENZYME-IMMUNOASSAY WITH A NEW MONOCLONAL EIA KIT", Voprosy virusologii, 42(6), 1997, pp. 271-275

Abstract

The formation of postvaccinal secretory immunity to influenza A and Bvirus was studied by a new monoclonal enzyme immunoassay test system for measuring specific secretory IgA in young people vaccinated with live cold-adapted vaccines (LCAV) intranasally and with inactivated commercial centrifuged influenza vaccine (IIV) parenterally, intranasally, and orally. Secretory IgA most intensively accumulated in subjects intranasally vaccinated with LCAV, less So in subjects vaccinated with IIV intranasally and orally, and just negligibly in those vaccinated with IIV parenterally. In vaccinees immunized with LCAV intranasally the intensity of immune secretory response depended on the initial concentrations of specific IgA before vaccination. Intranasal administration of LCAV in the presence of high concentrations of secretory IgA led in some subjects either to a decrease in the incidence of conversions or to a 2-8-fold drop of their initial titers. Parenteral injection ofIIV caused the most expressed suppression of the immune response in tile secretory immunity system; Use of biological stimulant adaptogen increased 2.2 times tile incidence of conversions of secretory IgA in subjects intranasally vaccinated with LCAV.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:56:51