Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECT OF CHRONIC FLUORIDE EXPOSURE IN UREMIC RATS
Autore:
DUNIPACE A; BRIZENDINE E; WILSON M; ZHANG W; WILSON C; KATZ B; KAFRAWY A; STOOKEY G;
Indirizzi:
ORAL HLTH RES INST,415 LANSING ST INDIANAPOLIS IN 46202 INDIANA UNIV,SCH MED,DIV BIOSTAT INDIANAPOLIS IN 00000 INDIANA UNIV,SCH DENT,DEPT STOMATOL INDIANAPOLIS IN 00000
Titolo Testata:
Nephron
fascicolo: 1, volume: 78, anno: 1998,
pagine: 96 - 103
SICI:
0028-2766(1998)78:1<96:EOCFEI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SISTER;
Keywords:
FLUORIDE METABOLISM; FLUORIDE TOXICITY; RENAL INSUFFICIENCY, FLUORIDE METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
A. Dunipace et al., "EFFECT OF CHRONIC FLUORIDE EXPOSURE IN UREMIC RATS", Nephron, 78(1), 1998, pp. 96-103

Abstract

This study was conducted to test the hypothesis that the margin of safe fluoride exposure is narrowed in rats that are physiologically compromised by renal dysfunction. The study objective was to determine whether increases in fluoride retention and tissue fluoride levels in rats with surgically induced renal insufficiency result in toxic fluorideeffects not ordinarily observed in healthy animals. Uremic and sham-operated control rats received 0 mu g/ml, 5 (0.26 mmol/l), 15 (0.79), or 50 mu g/ml (2.63 mmol/l) of fluoride in their drinking water for 3 or 6 months. Fluoride retention was monitored, and, following euthanasia, tissue fluoride and biochemical markers of tissue function were analyzed. Selected tissues were saved for histology, and bone marrow cells were harvested for determining the frequency of sister chromatid exchange, a marker of genetic damage. In spite of significantly higher levels of fluoride in the tissues of the animals with renal insufficiency, there were no clinically adverse, fluoride-induced, extraskeletal physiological, biochemical, or genetic effects of chronic exposure to common levels of fluoride in these rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 16:46:51