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Titolo:
CHANGES IN HUMAN MOTOR CORTEX EXCITABILITY INDUCED BY DOPAMINERGIC AND ANTIDOPAMINERGIC DRUGS
Autore:
ZIEMANN U; TERGAU F; BRUNS D; BAUDEWIG J; PAULUS W;
Indirizzi:
NINCDS,HUMAN MOTOR CONTROL SECT,NIH,BLDG 10,ROOM 5N242,10 CTR DR BETHESDA MD 20982 UNIV GOTTINGEN,DEPT CLIN NEUROPHYSIOL D-37075 GOTTINGEN GERMANY
Titolo Testata:
ELECTROMYOGRAPHY AND MOTOR CONTROL-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
fascicolo: 6, volume: 105, anno: 1997,
pagine: 430 - 437
SICI:
0924-980X(1997)105:6<430:CIHMCE>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRANIAL MAGNETIC STIMULATION; PARKINSONS-DISEASE; BASAL GANGLIA; CORTICOCORTICAL INHIBITION; CORTICAL EXCITABILITY; MOVEMENT-DISORDERS; GENERALIZED EPILEPSY; GLOBUS-PALLIDUS; CEREBRAL-CORTEX; NEURONS;
Keywords:
PAIRED TRANSCRANIAL MAGNETIC STIMULATION; MOTOR CORTEX; INTRACORTICAL INHIBITION AND FACILITATION; DOPAMINE RECEPTOR AGONISTS; NEUROLEPTICS;
Tipo documento:
Article
Natura:
Periodico
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
U. Ziemann et al., "CHANGES IN HUMAN MOTOR CORTEX EXCITABILITY INDUCED BY DOPAMINERGIC AND ANTIDOPAMINERGIC DRUGS", ELECTROMYOGRAPHY AND MOTOR CONTROL-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 105(6), 1997, pp. 430-437

Abstract

Transcranial magnetic stimulation was used to probe the acute effect of a single oral dose of various dopaminergic (levodopa, selegiline, bromocriptine) and antidopaminergic drugs (sulpiride, haloperidol) on motor cortex excitability in healthy volunteers. Motor threshold, intracortical inhibition and intracortical facilitation were tested in the abductor digiti minimi muscle. The latter two parameters were studied in a conditioning-test paired stimulus paradigm. The principal findings were an increase in intracortical inhibition by bromocriptine, and, conversely, a decrease in intracortical inhibition and an increase in intracortical facilitation by haloperidol. Effects peaked at delays consistent with the pharmacokinetics of the two drugs and were fully reversible. In conclusion, dopamine receptor agonists and antagonists canbe considered inverse modulators of motor cortex excitability: the former enhance inhibition while the latter reduce it. The relation of the present findings to current models of motor excitability abnormalities in movement disorders will be discussed. (C) 1997 Elsevier Science Ireland Ltd.

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Documento generato il 06/04/20 alle ore 08:42:03