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Titolo:
TRANSCRIPTIONAL ACTIVATION OF CYTOCHROME-P450 GENES BY DIFFERENT CLASSES OF CHEMICAL INDUCERS
Autore:
DOGRA SC; WHITELAW ML; MAY BK;
Indirizzi:
UNIV ADELAIDE,DEPT BIOCHEM ADELAIDE SA 5005 AUSTRALIA UNIV ADELAIDE,DEPT BIOCHEM ADELAIDE SA 5005 AUSTRALIA
Titolo Testata:
Clinical and experimental pharmacology and physiology
fascicolo: 1, volume: 25, anno: 1998,
pagine: 1 - 9
SICI:
0305-1870(1998)25:1<1:TAOCGB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR NUCLEAR TRANSLOCATOR; ARYL-HYDROCARBON RECEPTOR; ACID OMEGA-HYDROXYLASE; HELIX-LOOP-HELIX; HEAT-SHOCK PROTEIN; RAT CYP2B2 GENE; AH RECEPTOR; DIOXIN RECEPTOR; PEROXISOME PROLIFERATORS; CYP1A1 GENE;
Keywords:
ARYLHYDROCARBON RECEPTOR; CYTOCHROME P450; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOIDS; INDUCTION BY XENOBIOTICS; PEROXISOME PROLIFERATOR RECEPTOR; PEROXISOME PROLIFERATORS; PHENOBARBITAL; POLYCYCLIC AROMATIC HYDROCARBONS; TRANSCRIPTIONAL CONTROL;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
80
Recensione:
Indirizzi per estratti:
Citazione:
S.C. Dogra et al., "TRANSCRIPTIONAL ACTIVATION OF CYTOCHROME-P450 GENES BY DIFFERENT CLASSES OF CHEMICAL INDUCERS", Clinical and experimental pharmacology and physiology, 25(1), 1998, pp. 1-9

Abstract

1. We review here the molecular mechanisms underlying the xenobiotic induction of genes encoding cytochrome P450 (CYP) enzymes in the liverand other tissues. We will focus on four major families of CYP genes,2. Members of the CYP1 gene family are induced by polycyclic aromatichydrocarbons and this process is mediated by the basic helix-loop-helix proteins: the Ah receptor and its heterodimeric partner Arnt, Considerable progress has been made in elucidating the molecular details ofthis induction process, 3. CYP4 genes are activated by peroxisomal proliferators, a group of structurally diverse chemicals that also induce peroxisome proliferation, The transcriptional response is dependent on the peroxisome proliferator-activated receptor and its partner RXR,both members of the nuclear receptor superfamily; their role in the induction process has been well characterized at the molecular level, 4. In contrast, the mechanism of gene induction of CYP2 genes by phenobarbital and other structurally diverse inducers is not well understoodand a specific phenobarbital-responsive receptor has not been identified, 5. Induction of the CYP3 gene family by the glucocorticoid dexamethasone appears to involve the glucocorticoid receptor, but this receptor is not apparently required for induction by metapyrone and a complete molecular understanding of the induction processes is lacking at present.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:59:56