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Titolo:
ASSOCIATION BETWEEN THE TRYPTOPHAN-HYDROXYLASE GENE AND MANIC-DEPRESSIVE ILLNESS
Autore:
BELLIVIER F; LEBOYER M; COURTET P; BURESI C; BEAUFILS B; SAMOLYK D; ALLILAIRE JF; FEINGOLD J; MALLET J; MALAFOSSE A;
Indirizzi:
HOP LA PITIE SALPETRIERE,LAB RECH PERSONNALITES & CONDUITES ADAPTAT,CNRS,URA 1957 F-75013 PARIS FRANCE HOP LA PITIE SALPETRIERE,SERV PSYCHIAT ADULTE F-75013 PARIS FRANCE HOP LA PITIE SALPETRIERE,LAB GENET NEUROTRANSMISS & PROC NEURODEGENERAT F-75013 PARIS FRANCE LAB EPIDEMIOL GENET PARIS FRANCE HOP CORENTIN CELTON,SERV PSYCHIAT ADULTE ISSY LES MOULINEAUX FRANCE UNIV HOSP GENEVA,DIV NEUROPSYCHIAT GENEVA SWITZERLAND
Titolo Testata:
Archives of general psychiatry
fascicolo: 1, volume: 55, anno: 1998,
pagine: 33 - 37
SICI:
0003-990X(1998)55:1<33:ABTTGA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BIPOLAR AFFECTIVE-DISORDER; MONOAMINE-OXIDASE-A; CEREBROSPINAL-FLUID; SEROTONIN TRANSPORTER; IMIPRAMINE BINDING; BLOOD-PLATELETS; SUICIDE; SUSCEPTIBILITY; POLYMORPHISM; BEHAVIOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
F. Bellivier et al., "ASSOCIATION BETWEEN THE TRYPTOPHAN-HYDROXYLASE GENE AND MANIC-DEPRESSIVE ILLNESS", Archives of general psychiatry, 55(1), 1998, pp. 33-37

Abstract

Background: Genes encoding proteins involved in serotonergic metabolism are major candidates in association studies of mood disorders and suicidal behavior. This association study explores whether the tryptophan hydroxylase (TPH) gene, which codes for the rate-limiting enzyme ofserotonin biosynthesis, is a susceptibility factor for manic-depressive illness, with or without a history of suicide attempts. Methods: The TPH intron 7 A218C polymorphism was determined using a polymerase chain reaction-based method in DNA samples from 152 patients with bipolar disorder and 94 healthy control subjects. Results: There was a significant association between TPH genotypes and manic-depressive illness. Among patients with bipolar disorder, no association was found between TPH alleles and suicidal behavior. Conclusions: This result suggeststhe involvement of the TPH gene in susceptibility to manic-depressiveillness. This preliminary result requires confirmation in further groups of patients and controls.

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Documento generato il 24/01/20 alle ore 15:46:31