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Titolo:
ISOLATION OF THE GENE ENCODING LAMP-1, A LYSOSOMAL MEMBRANE-PROTEIN, BY DIFFERENTIAL SCREENING IN AN ANIMAL-MODEL OF STATUS EPILEPTICUS
Autore:
SUN N; BRUCE AJ; BAUDRY M; SCHREIBER SS;
Indirizzi:
UNIV SO CALIF,SCH MED,DEPT NEUROL,1333 SAN PABLO ST,MCH 142 LOS ANGELES CA 90033 UNIV SO CALIF,SCH MED,DEPT NEUROL LOS ANGELES CA 90033 UNIV SO CALIF,NEUROSCI PROGRAM LOS ANGELES CA 90089
Titolo Testata:
Molecular brain research
fascicolo: 2, volume: 45, anno: 1997,
pagine: 353 - 355
SICI:
0169-328X(1997)45:2<353:IOTGEL>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
KAINIC ACID; NEURONAL DAMAGE; CELL-DEATH; MECHANISMS; EXPRESSION; BRAIN; ADULT;
Keywords:
SELECTIVE NEURONAL VULNERABILITY; LYSOSOMAL; GENE EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
N. Sun et al., "ISOLATION OF THE GENE ENCODING LAMP-1, A LYSOSOMAL MEMBRANE-PROTEIN, BY DIFFERENTIAL SCREENING IN AN ANIMAL-MODEL OF STATUS EPILEPTICUS", Molecular brain research, 45(2), 1997, pp. 353-355

Abstract

The present study employed differential library screening to identifygenes associated with kainic acid (KA)-mediated selective neuronal death. One of the isolated clones was lamp-1, which encodes a major lysosomal membrane protein that is also present in the cell membrane. Following systemic KA treatment, lamp-1 was induced in vulnerable hippocampal and other Limbic regions. This effect was blocked by cycloheximide(CHX) pre-treatment. Northern blot analysis also demonstrated the presence of lamp-1 transcripts in non-neural tissues. These findings suggest a novel role for lysosomal membrane proteins as markers of selective neuronal vulnerability. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 22:02:24