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Titolo:
EMERGENCE OF MYCOBACTERIUM-AVIUM POPULATIONS RESISTANT TO MACROLIDES DURING EXPERIMENTAL CHEMOTHERAPY
Autore:
BERMUDEZ LE; PETROFSKY M; KOLONOSKI P; YOUNG LS;
Indirizzi:
CALIF PACIFIC MED CTR,RES INST,KUZELL INST ARTHRITIS & INFECT DIS,2200 WEBSTER ST,SUITE 305 SAN FRANCISCO CA 94115
Titolo Testata:
Antimicrobial agents and chemotherapy
fascicolo: 1, volume: 42, anno: 1998,
pagine: 180 - 183
SICI:
0066-4804(1998)42:1<180:EOMPRT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; COMPLEX INFECTION; BEIGE MICE; CLARITHROMYCIN; AZITHROMYCIN; INTRACELLULARE; AIDS; PROPHYLAXIS; DISEASE; INVITRO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
L.E. Bermudez et al., "EMERGENCE OF MYCOBACTERIUM-AVIUM POPULATIONS RESISTANT TO MACROLIDES DURING EXPERIMENTAL CHEMOTHERAPY", Antimicrobial agents and chemotherapy, 42(1), 1998, pp. 180-183

Abstract

Macrolide resistance is an emerging problem in AIDS patients who receive these agents for treatment or prophylaxis against Mycobacterium avium (MAC) infection, We compared the emergence of resistant MAC strains during therapy with clarithromycin (clarithromycin resistance was defined as MIC greater than or equal to 32 mu g/ml) and azithromycin (azithromycin resistance was defined as MIC greater than or equal to 128 mu g/ml) in C57BL/6 beige mice. Treatment with clarithromycin and azithromycin resulted in a decrease of 98.5% in the number of viable bacteria in spleens at week 8 and 99% at week 12 compared with the number of bacteria present in spleen before the initiation of therapy (P < 0.001). Splenic homogenates were also plated onto 7H11 agar plus clarithromycin at 32 mu g/ml or azithromycin at 128 mu g/ml. Resistance emerged significantly more often in mice treated with clarithromycin (100% of treated mice at both 8 and 12 weeks) than in those receiving azithromycin (0% at week 8 and 14% at week 12). The frequencies of resistanceof the MAC population in the spleen to clarithromycin were 2.1 x 10(-3) at week 8 and 1.1 x 10(-2) at week 12, whereas resistance to azithromycin was absent at week 8 (all mice) and was similar to 3.5 x 10(-5)(mean for the three positive animals) at week 12. Clarithromycin was more effective in initial reduction of MAC burden in tissue after 8 and 12 week of treatment, but resistant strains emerged significantly more frequently after treatment with clarithromycin than after treatmentwith azithromycin.

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Documento generato il 01/10/20 alle ore 06:30:24