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Titolo:
EFFECT OF AMINOGUANIDINE, A NITRIC-OXIDE SYNTHASE INHIBITOR, ON SCIATIC-NERVE CRUSH INJURY IN RATS
Autore:
TARIQ M; ARSHADUDDIN M; BIARY N; ALDEEB S; ALMOUTAERY K;
Indirizzi:
ARMED FORCES HOSP,RES CTR,NEUROSCI RES GRP,W-912,POB 7897 RIYADH 11159 SAUDI ARABIA
Titolo Testata:
Medical science research
fascicolo: 12, volume: 25, anno: 1997,
pagine: 815 - 818
SICI:
0269-8951(1997)25:12<815:EOAANS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
VITAMIN-E; INDUCED DYSKINESIA; FATTY ACYLATION; TIBIAL NERVE; REGENERATION; CELLS; SUPEROXIDE; PERONEAL; PROTEIN; BRAIN;
Keywords:
SCIATIC NERVE INJURY; AMINOGUANIDINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
M. Tariq et al., "EFFECT OF AMINOGUANIDINE, A NITRIC-OXIDE SYNTHASE INHIBITOR, ON SCIATIC-NERVE CRUSH INJURY IN RATS", Medical science research, 25(12), 1997, pp. 815-818

Abstract

We studied the effect of aminoguanidine, a nitric oxide synthase (NOS) inhibitor on the recovery pattern of crush injured sciatic nerves inrats. Injury was produced by crushing the sciatic nerve with a haemostat for 30 s under deep anaesthesia. Different groups of animals were treated with aminoguanidine at concentrations of 0.25, 0.5 and 1.0g kg(-1) by gavage 1 h before injury and then daily for 1, 7, 14 and 21 days. Functional response, muscle action potential amplitude and levels of alpha-tocopherol in sciatic nerve were recorded at different time intervals. Sciatic nerve injury resulted in a significant reduction in the functional response, which gradually recovered over a period of 3 weeks. Our electrophysiological and biochemical studies showed a significant decrease in the compound muscle action potential and vitamin E which did not show recovery over the 3 weeks period of study. Treatment of animals with aminoguanidine failed to produce any changes in the pattern of functional and electrophysiological recovery as compared tountreated animals. The result of this study clearly suggest that modulation of nitric oxide by aminoguanidine does not protect animals against crush-induced functional deficiency.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 03:32:53